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IgG4-related orbital disease: a meta-analysis and review

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dc.contributor.authorAndrew, N.
dc.contributor.authorKearney, D.
dc.contributor.authorSelva-Nayagam, D.
dc.date.issued2012
dc.description.abstractIgG4-related orbital disease (IgG4-ROD) is a recently described condition that may account for a significant proportion of idiopathic lymphoplasmacytic or sclerotic orbital lesions. This study is the first meta-analysis of published cases and reveals several differences between IgG4-related disease affecting the orbit and that affecting the pancreas. IgG4-ROD affects a slightly younger group of patients, affects men and women approximately equally, is commonly associated with salivary gland lesions, is associated with a relatively higher serum IgG4 and may confer an increased risk of non-Hodgkin Lymphoma. Its pathogenesis may involve an immune response to antigen exposure in the upper aerodigestive tract.
dc.description.statementofresponsibilityNicholas Andrew, Daniel Kearney and Dinesh Selva
dc.identifier.citationActa Ophthalmologica, 2012; online(8):1-7
dc.identifier.doi10.1111/j.1755-3768.2012.02526.x
dc.identifier.issn1755-375X
dc.identifier.issn1755-3768
dc.identifier.orcidSelva-Nayagam, D. [0000-0002-2169-5417]
dc.identifier.urihttp://hdl.handle.net/2440/77705
dc.language.isoen
dc.publisherWiley-Blackwell Munksgaard
dc.rights© 2012 The Authors.
dc.source.urihttps://doi.org/10.1111/j.1755-3768.2012.02526.x
dc.subjectdacryoadenitis
dc.subjectIgG4
dc.subjectIgG4-related disease
dc.subjectIgG4-related orbital disease
dc.subjectorbital
dc.subjectreview
dc.titleIgG4-related orbital disease: a meta-analysis and review
dc.typeJournal article
pubs.publication-statusPublished

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