Donors With a Prior History of Cancer: Factors of Non-Utilization of Kidneys for Transplantation
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Date
2023
Authors
Lim, W.H.
Au, E.
Teixeira-Pinto, A.
Ooi, E.
Opdam, H.
Chapman, J.
Johnson, D.W.
Kanellis, J.
Davies, C.E.
Wong, G.
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Journal article
Citation
Transplant International, 2023; 36(10):11883-1-11883-12
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Wai H. Lim, Eric Au, Armando Teixeira-Pinto, Esther Ooi, Helen Opdam, Jeremy Chapman, David W. Johnson, John Kanellis, Christopher E. Davies and Germaine Wong
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Abstract
Cancer transmission from deceased donors is an exceedingly rare but potentially fatal complication in transplant recipients. We aimed to quantify the likelihood of non-utilization of kidneys for transplantation from donors with a prior cancer history. We included all intended and actual deceased donors in Australia and New Zealand between 1989 and 2017. Association between prior cancer history and non-utilization of donor kidneys was examined using adjusted logistic regression. Of 9,485 deceased donors, 345 (4%) had a prior cancer history. Of 345 donors with a prior cancer history, 197 (57%) were utilized for transplantation. Donor characteristics of age, sex and comorbidities were similar between utilized and non-utilized donors with prior cancer. The time from cancer to organ donation was similar between utilized and non-utilized donors, irrespective of cancer subtypes. Donors with a prior cancer history were less likely to be utilized [adjusted OR (95% CI) 2.29 (1.68–3.13)] than donors without prior cancer. Of all actual donors, the adjusted OR for non-utilization among those with prior cancer was 2.36 (1.58–3.53). Non-melanoma skin cancer was the most frequent prior cancer type for utilized and non-utilized potential donors. Donors with prior cancers were less likely to be utilized for transplantation, with no discernible differences in cancer characteristics between utilized and non-utilized donors.
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Published: 31 October 2023
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© 2023 Lim, Au, Teixeira-Pinto, Ooi, Opdam, Chapman, Johnson, Kanellis, Davies and Wong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.