Altered Insulin-Like Growth Factor binding Proteins
Date
2009
Authors
Forbes, B.
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Patent
Citation
Statement of Responsibility
Inventor B. Forbes; Assigned to University of Adelaide; Foley & Lardner LLP agents for inventor.
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Abstract
Altered IGFBPs are able to bind IGF, but the release is inhibited by resistance to protease cleavage and/or reduced binding to extracellular matrix (ECM). Alterations have been made in IGFBP-2 to the linker domain in particular and to two amino acid motifs found to be important for ECM binding. IGF-1 mediated proliferation of cancer cells have been inhibited by use of the altered IGFBPs.
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Description
PATENT: B. Forbes (Assignee: University of Adelaide). US 7488798 (PCT/AU03/00898) filed Jul 11, 2003; published Feb 10, 2009; predicted expiry Jul 11, 2023.