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Challenges and opportunities in nanotherapeutics targeted for central nervous system disorders

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dc.contributor.authorYong, J.
dc.contributor.authorHakobyan, K.
dc.contributor.authorMahmud, S.A.Z.
dc.contributor.authorJohnson, D.J.
dc.contributor.authorLee, J.
dc.contributor.authorDiwan, A.D.
dc.contributor.authorGu, S.
dc.contributor.authorMoalem-Taylor, G.
dc.contributor.authorMao, G.
dc.date.issued2025
dc.description.abstractCentral nervous system (CNS) disorders represent some of the most challenging problems for modern medicine. The complexity of the CNS structure, incomplete understanding of disease, chronic neuroinflammation, and physiological barriers limiting drug delivery all contribute to the difficulty of treating neurological diseases. This review covers the neuroanatomical barriers of the CNS and discusses current treatments, shortcomings of these treatments, recent clinical trials, and opportunities for nanotherapeutic approaches in common CNS disorders. Focus is placed on selected CNS disorders stemming from trauma, neurodegenerative diseases and infectious diseases. The review concludes with a summary and perspectives on the nanotherapeutics development highlighting key challenges and future directions for the field.
dc.description.statementofresponsibilityJoel Yong, Karen Hakobyan, Sk Al Zaheri Mahmud, Daniel James Johnson, Jacob Lee, Ashish D. Diwan, Sophia Gu, Gila Moalem-Taylor, Guangzhao Mao
dc.identifier.citationNanoscale, 2025; 17(43):24860-24896
dc.identifier.doi10.1039/d5nr02463c
dc.identifier.issn2040-3364
dc.identifier.issn2040-3372
dc.identifier.orcidDiwan, A.D. [0000-0003-1037-8421]
dc.identifier.urihttps://hdl.handle.net/2440/148527
dc.language.isoen
dc.publisherRoyal Society of Chemistry
dc.relation.granthttp://purl.org/au-research/grants/arc/DP230102641
dc.rights© The Royal Society of Chemistry 2025. Open Access Article. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
dc.source.urihttps://doi.org/10.1039/d5nr02463c
dc.subjectcentral nervous system; neuroinflammation; nanotherapeutics; drug delivery barriers
dc.subject.meshAnimals
dc.subject.meshHumans
dc.subject.meshCentral Nervous System Diseases
dc.subject.meshNeurodegenerative Diseases
dc.subject.meshDrug Delivery Systems
dc.subject.meshNanomedicine
dc.subject.meshNanoparticles
dc.titleChallenges and opportunities in nanotherapeutics targeted for central nervous system disorders
dc.typeJournal article
pubs.publication-statusPublished online

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