Acute Effects of Lixisenatide on Energy Intake in Healthy Subjects and Patients with Type 2 Diabetes: Relationship to Gastric Emptying and Intragastric Distribution.

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dc.contributor.authorJalleh, R.
dc.contributor.authorPham, H.
dc.contributor.authorMarathe, C.S.
dc.contributor.authorWu, T.
dc.contributor.authorButtfield, M.D.
dc.contributor.authorHatzinikolas, S.
dc.contributor.authorMalbert, C.H.
dc.contributor.authorRigda, R.S.
dc.contributor.authorLange, K.
dc.contributor.authorTrahair, L.G.
dc.contributor.authorFeinle-Bisset, C.
dc.contributor.authorRayner, C.K.
dc.contributor.authorHorowitz, M.
dc.contributor.authorJones, K.L.
dc.date.issued2020
dc.description.abstractGlucagon-like peptide-1 receptor agonists induce weight loss, which has been suggested to relate to the slowing of gastric emptying (GE). In health, energy intake (EI) is more strongly related to the content of the distal, than the total, stomach. We evaluated the effects of lixisenatide on GE, intragastric distribution, and subsequent EI in 15 healthy participants and 15 patients with type 2 diabetes (T2D). Participants ingested a 75-g glucose drink on two separate occasions, 30 min after lixisenatide (10 mcg) or placebo subcutaneously, in a randomised, double-blind, crossover design. GE and intragastric distribution were measured for 180 min followed by a buffet-style meal, where EI was quantified. Relationships of EI with total, proximal, and distal stomach content were assessed. In both groups, lixisenatide slowed GE markedly, with increased retention in both the proximal (p < 0.001) and distal (p < 0.001) stomach and decreased EI (p < 0.001). EI was not related to the content of the total or proximal stomach but inversely related to the distal stomach at 180 min in health on placebo (r = –0.58, p = 0.03) but not in T2D nor after lixisenatide in either group. In healthy and T2D participants, the reduction in EI by lixisenatide is unrelated to changes in GE/intragastric distribution, consistent with a centrally mediated effect.
dc.description.statementofresponsibilityRyan Jalleh, Hung Pham, Chinmay S. Marathe, Tongzhi Wu, Madeline D. Buttfield, Seva Hatzinikolas, Charles H. Malbert, Rachael S. Rigda, Kylie Lange, Laurence G. Trahair, Christine Feinle-Bisset, Christopher K. Rayner, Michael Horowitz, and Karen L. Jones
dc.identifier.citationNutrients, 2020; 12(7):1962-1-1962-8
dc.identifier.doi10.3390/nu12071962
dc.identifier.issn2072-6643
dc.identifier.issn2072-6643
dc.identifier.orcidJalleh, R. [0000-0003-4969-4771]
dc.identifier.orcidPham, H. [0000-0002-7055-3108]
dc.identifier.orcidWu, T. [0000-0003-1656-9210]
dc.identifier.orcidMalbert, C.H. [0000-0002-0665-4545]
dc.identifier.orcidRigda, R.S. [0000-0002-8924-5359]
dc.identifier.orcidLange, K. [0000-0003-3814-8513]
dc.identifier.orcidFeinle-Bisset, C. [0000-0001-6848-0125]
dc.identifier.orcidRayner, C.K. [0000-0002-5527-256X]
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]
dc.identifier.orcidJones, K.L. [0000-0002-1155-5816]
dc.identifier.urihttps://hdl.handle.net/2440/145898
dc.language.isoen
dc.publisherMDPI AG
dc.relation.grantNHMRC
dc.rights© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.source.urihttps://doi.org/10.3390/nu12071962
dc.subjectlixisenatide; intragastric meal retention; energy intake; type 2 diabetes
dc.subject.meshStomach
dc.subject.meshHumans
dc.subject.meshDiabetes Mellitus, Type 2
dc.subject.meshGlucose
dc.subject.meshPeptides
dc.subject.meshPlacebos
dc.subject.meshHypoglycemic Agents
dc.subject.meshCross-Over Studies
dc.subject.meshDouble-Blind Method
dc.subject.meshEnergy Intake
dc.subject.meshGastric Emptying
dc.subject.meshBeverages
dc.subject.meshAged
dc.subject.meshMiddle Aged
dc.subject.meshFemale
dc.subject.meshMale
dc.subject.meshMeals
dc.subject.meshGlucagon-Like Peptide-1 Receptor
dc.titleAcute Effects of Lixisenatide on Energy Intake in Healthy Subjects and Patients with Type 2 Diabetes: Relationship to Gastric Emptying and Intragastric Distribution.
dc.typeJournal article
pubs.publication-statusPublished

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