IL7RA polymorphisms and chronic inflammatory arthropathies
Date
2009
Authors
O'Doherty, C.
Alloza, I.
Rooney, M.
Vandenbroeck, K.
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Tissue Antigens: immune response genetics, 2009; 74(5):429-431
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Abstract
The C allele of a single nucleotide polymorphism (SNP), rs6897932, located in the interleukin‐7 receptor alpha chain (IL7RA) was recently found to be associated with multiple sclerosis and Type I diabetes. We analysed 13 SNPs in the IL7RA gene in a combined cohort of patients with chronic inflammatory arthropathies (rheumatoid arthritis and juvenile idiopathic arthritis; 368 patients and 532 unaffected subjects). No significant associations with disease were found with the exception of the non‐synonymous SNP rs6897932. This SNP showed modest enrichment of the TT genotype in arthritic patients compared with controls [P = 0.02; OR 1.72 (95% CI 1.08–2.75)]. Our data are suggestive for a role of rs6897932 in predisposition to chronic inflammatory arthropathies.
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Copyright 2009 John Wiley & Sons