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IL7RA polymorphisms and chronic inflammatory arthropathies

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dc.contributor.authorO'Doherty, C.
dc.contributor.authorAlloza, I.
dc.contributor.authorRooney, M.
dc.contributor.authorVandenbroeck, K.
dc.date.issued2009
dc.description.abstractThe C allele of a single nucleotide polymorphism (SNP), rs6897932, located in the interleukin‐7 receptor alpha chain (IL7RA) was recently found to be associated with multiple sclerosis and Type I diabetes. We analysed 13 SNPs in the IL7RA gene in a combined cohort of patients with chronic inflammatory arthropathies (rheumatoid arthritis and juvenile idiopathic arthritis; 368 patients and 532 unaffected subjects). No significant associations with disease were found with the exception of the non‐synonymous SNP rs6897932. This SNP showed modest enrichment of the TT genotype in arthritic patients compared with controls [P = 0.02; OR 1.72 (95% CI 1.08–2.75)]. Our data are suggestive for a role of rs6897932 in predisposition to chronic inflammatory arthropathies.
dc.identifier.citationTissue Antigens: immune response genetics, 2009; 74(5):429-431
dc.identifier.doi10.1111/j.1399-0039.2009.01342.x
dc.identifier.issn0001-2815
dc.identifier.issn1399-0039
dc.identifier.urihttps://hdl.handle.net/11541.2/112827
dc.language.isoen
dc.publisherWiley-Blackwell
dc.relation.fundingNorthern Ireland HPSS R&D Office RSG/1726
dc.rightsCopyright 2009 John Wiley & Sons
dc.source.urihttps://doi.org/10.1111/j.1399-0039.2009.01342.x
dc.subjectinterleukin-7 receptor
dc.subjectarthritis
dc.subjectmultiple sclerosis
dc.subjectdiabetes
dc.subjectinflammatory arthropathies
dc.titleIL7RA polymorphisms and chronic inflammatory arthropathies
dc.typeJournal article
pubs.publication-statusPublished
ror.mmsid9915910713501831

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