Evidence for circulatory benefits of resveratrol in humans
Date
2013
Authors
Wong, R.H.X.
Coates, A.M.
Buckley, J.D.
Howe, P.
Editors
Brown, K.
Vang, O.
Vang, O.
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Annals of the New York Academy of Sciences, 2013; 1290(1):52-58
Statement of Responsibility
Conference Name
Abstract
Impairments of endothelial function, which can be assessed noninvasively by flow-mediated dilation (FMD) of the brachial artery, contribute to the development of cardiovascular disease. Associations between FMD and cognition suggest a vascular component in the loss of cognitive function. Certain vasoactive nutrients that have been shown to improve FMD may also have the potential to enhance cerebral perfusion and cognition. Preclinical studies show that trans-resveratrol can enhance nitric oxide bioavailability, thereby increasing endothelium-dependent vasodilation. We have now shown that acute administration of resveratrol elicits dose-dependent increases of FMD with greater potency than other vasoactive nutrients and that this benefit is sustained following regular consumption. We describe the potential implications of this vasodilator benefit of resveratrol and its role in enhancing cerebrovascular and cognitive functions.
School/Discipline
Dissertation Note
Provenance
Description
Access Status
Rights
Copyright 2013 New York Academy of Sciences