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Evidence for circulatory benefits of resveratrol in humans

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dc.contributor.authorWong, R.H.X.
dc.contributor.authorCoates, A.M.
dc.contributor.authorBuckley, J.D.
dc.contributor.authorHowe, P.
dc.contributor.editorBrown, K.
dc.contributor.editorVang, O.
dc.date.issued2013
dc.description.abstractImpairments of endothelial function, which can be assessed noninvasively by flow-mediated dilation (FMD) of the brachial artery, contribute to the development of cardiovascular disease. Associations between FMD and cognition suggest a vascular component in the loss of cognitive function. Certain vasoactive nutrients that have been shown to improve FMD may also have the potential to enhance cerebral perfusion and cognition. Preclinical studies show that trans-resveratrol can enhance nitric oxide bioavailability, thereby increasing endothelium-dependent vasodilation. We have now shown that acute administration of resveratrol elicits dose-dependent increases of FMD with greater potency than other vasoactive nutrients and that this benefit is sustained following regular consumption. We describe the potential implications of this vasodilator benefit of resveratrol and its role in enhancing cerebrovascular and cognitive functions.
dc.identifier.citationAnnals of the New York Academy of Sciences, 2013; 1290(1):52-58
dc.identifier.doi10.1111/nyas.12155
dc.identifier.issn0077-8923
dc.identifier.issn1749-6632
dc.identifier.orcidBuckley, J.D. [0000-0003-0298-2186]
dc.identifier.orcidHowe, P. [0000-0001-6546-7742]
dc.identifier.urihttps://hdl.handle.net/1959.8/152231
dc.language.isoen
dc.publisherWiley-Blackwell
dc.rightsCopyright 2013 New York Academy of Sciences
dc.source.urihttps://doi.org/10.1111/nyas.12155
dc.subjectendothelial function
dc.subjectflow-mediated dilation
dc.subjecthuman
dc.subjectresveratrol
dc.subjecttrans-resveratrol
dc.subjectvasodilator responsiveness
dc.subjectAnimals
dc.subjectHumans
dc.subjectCardiovascular Diseases
dc.subjectStilbenes
dc.subjectVasodilator Agents
dc.titleEvidence for circulatory benefits of resveratrol in humans
dc.typeJournal article
pubs.publication-statusPublished
ror.mmsid9915909867201831

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