Roles of Notch2 signalling pathway in bone & bone marrow micro-vasculature damage following methotrexate chemotherapy in rats /
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(Published version)
Date
2021
Authors
Peymanfar, Yaser
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thesis
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Abstract
Methotrexate (MTX) is most notably used for the treatment of the paediatric cancer acute lymphoblastic leukemia (ALL), breast cancer and osteosarcoma. Despite a high rate of success in the cancer treatment, long-term adverse effects of chemotherapy on bone/bone marrow such as bone loss, marrow adiposity and bone marrow vasculature injuries have been reported among cancer patients and in experimental studies. However, the underlying molecular mechanisms of damage and recovery potential are poorly understood. Current research with in vitro and in vivo studies and using a vast range of techniques has identified that deregulation of Notch2 signalling plays an important role in mediating MTX-induced bone/bone marrow damage. Our findings illustrate that targeting Notch2 could be a potential treatment option to overcome MTX chemotherapy bone-related adverse effects.
School/Discipline
University of South Australia. UniSA Clinical and Health Sciences.
UniSA Clinical and Health Sciences
UniSA Clinical and Health Sciences
Dissertation Note
Thesis (PhD(Medical Science))--University of South Australia, 2021.
Provenance
Copyright 2021 Yaser Peymanfar.
Description
1 ethesis (xv, 162 pages) :
colour illustrations, colour charts.
Includes bibliographical references (pages 126-162)
colour illustrations, colour charts.
Includes bibliographical references (pages 126-162)
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506 0#$fstar $2Unrestricted online access