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Roles of Notch2 signalling pathway in bone & bone marrow micro-vasculature damage following methotrexate chemotherapy in rats /

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dc.contributor.authorPeymanfar, Yaser
dc.contributor.schoolUniversity of South Australia. UniSA Clinical and Health Sciences.
dc.contributor.schoolUniSA Clinical and Health Sciences
dc.date.issued2021
dc.description1 ethesis (xv, 162 pages) :
dc.descriptioncolour illustrations, colour charts.
dc.descriptionIncludes bibliographical references (pages 126-162)
dc.description.abstractMethotrexate (MTX) is most notably used for the treatment of the paediatric cancer acute lymphoblastic leukemia (ALL), breast cancer and osteosarcoma. Despite a high rate of success in the cancer treatment, long-term adverse effects of chemotherapy on bone/bone marrow such as bone loss, marrow adiposity and bone marrow vasculature injuries have been reported among cancer patients and in experimental studies. However, the underlying molecular mechanisms of damage and recovery potential are poorly understood. Current research with in vitro and in vivo studies and using a vast range of techniques has identified that deregulation of Notch2 signalling plays an important role in mediating MTX-induced bone/bone marrow damage. Our findings illustrate that targeting Notch2 could be a potential treatment option to overcome MTX chemotherapy bone-related adverse effects.
dc.description.dissertationThesis (PhD(Medical Science))--University of South Australia, 2021.
dc.identifier.urihttps://hdl.handle.net/11541.2/25258
dc.language.isoen
dc.provenanceCopyright 2021 Yaser Peymanfar.
dc.subjectbone;vasculature;chemotherapy
dc.subject.lcshBone marrow
dc.subject.lcshBones
dc.subject.lcshCancer
dc.subject.lcshMethotrexate
dc.titleRoles of Notch2 signalling pathway in bone & bone marrow micro-vasculature damage following methotrexate chemotherapy in rats /
dc.typethesis
dcterms.accessRights506 0#$fstar $2Unrestricted online access
ror.fileinfo12232441860001831 13232441850001831 Peymanfar, Yaser - Thesis
ror.mmsid9916562088501831

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