MASCC/ISOO clinical practice guidelines for the management of mucositis: sub-analysis of current interventions for the management of oral mucositis in pediatric cancer patients

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dc.contributor.authorMiranda-Silva, W.
dc.contributor.authorGomes-Silva, W.
dc.contributor.authorZadik, Y.
dc.contributor.authorYarom, N.
dc.contributor.authorAl-Azri, A.R.
dc.contributor.authorHong, C.H.L.
dc.contributor.authorAriyawardana, A.
dc.contributor.authorSaunders, D.P.
dc.contributor.authorCorrea, M.E.
dc.contributor.authorArany, P.R.
dc.contributor.authorBowen, J.
dc.contributor.authorCheng, K.K.F.
dc.contributor.authorTissing, W.J.E.
dc.contributor.authorBossi, P.
dc.contributor.authorElad, S.
dc.date.issued2021
dc.description.abstractObjective: The aim of this sub-analysis was to highlight the MASCC/ISOO clinical practice guidelines for the management of oral mucositis (OM) in pediatric patients and to present unique considerations in this patient population. Methods: This sub-analysis of the pediatric patient population is based on the systematic review conducted by the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISSO) published in 2019/2020. Studies were scored and assigned a level of evidence based on previously published criteria. Data regarding adverse effects and compliance was collected from the original publications. Results: A total of 45 papers were included and assessed in this sub-analysis, including 21 randomized controlled trials (RCTs). Chewing gum was demonstrated to be not effective in preventing OM in pediatric cancer patients in 2 RCTs. The efficacy of all other interventions could not be determined based on the available literature. Conclusion: There is limited or conflicting evidence about interventions for the management of OM in pediatric cancer patients, except for chewing gum which was ineffective for prevention. Therefore, currently, data from adult studies may need to be extrapolated for the management of pediatric patients. Honey and photobiomodulation therapy in this patient population had encouraging potential. Implementation of a basic oral care protocol is advised amid lack of high level of evidence studies.
dc.description.statementofresponsibilityWanessa Miranda-Silva, Wagner Gomes-Silva, Yehuda Zadik, Noam Yarom, Abdul Rahman Al-Azri, Catherine H. L. Hong, Anura Ariyawardana, Deborah P. Saunders, M. Elvira Correa, Praveen R. Arany, Joanne Bowen, Karis Kin Fong Cheng, Wim J. E. Tissing, Paolo Bossi, Sharon Elad, On behalf of the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer, International Society for Oral Oncology, MASCC, ISOO
dc.identifier.citationSupportive Care in Cancer, 2021; 29(7):3539-3562
dc.identifier.doi10.1007/s00520-020-05803-4
dc.identifier.issn0941-4355
dc.identifier.issn1433-7339
dc.identifier.orcidAl-Azri, A.R. [0000-0002-2618-9679]
dc.identifier.orcidBowen, J. [0000-0003-0876-0031]
dc.identifier.urihttps://hdl.handle.net/2440/145779
dc.language.isoen
dc.publisherSpringer
dc.rights© Springer-Verlag GmbH Germany, part of Springer Nature 2020
dc.source.urihttps://doi.org/10.1007/s00520-020-05803-4
dc.subjectCancer; Prevention; Treatment; Oral mucositis; Pain; Pediatric patients; Evidence-based; Guidelines
dc.subject.meshHumans
dc.subject.meshStomatitis
dc.subject.meshAdolescent
dc.subject.meshChild
dc.subject.meshGuidelines as Topic
dc.titleMASCC/ISOO clinical practice guidelines for the management of mucositis: sub-analysis of current interventions for the management of oral mucositis in pediatric cancer patients
dc.typeJournal article
pubs.publication-statusPublished

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