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Changes in antibiotic distribution due to pancreatitis

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dc.contributor.authorFanning, K.J.
dc.contributor.authorRobertson, T.A.
dc.contributor.authorPrins, J.B.
dc.contributor.authorRoberts, M.S.
dc.date.issued2011
dc.description.abstractThis work sought to define how pancreatitis affected antibiotic distribution in a perfused rat pancreas model. The distribution kinetics of four antibiotics were examined in control animals and animals with pancreatitis. Meropenem and piperacillin distributed into the extracellular space, and their distribution kinetics were unaffected by pancreatitis. In contrast, in pancreatic cells from animals with pancreatitis, ciprofloxacin showed a reduced uptake and clindamycin showed a reduced distribution.
dc.identifier.citationAntimicrobial Agents and Chemotherapy, 2011; 55(6):3008-3011
dc.identifier.doi10.1128/AAC.00416-10
dc.identifier.issn0066-4804
dc.identifier.issn1098-6596
dc.identifier.urihttps://hdl.handle.net/1959.8/123640
dc.language.isoen
dc.publisherAmerican Society for Microbiology
dc.relation.fundingNHMRC
dc.relation.fundingUniversity of Queensland
dc.rightsCopyright 2011 American Society for Microbiology
dc.source.urihttps://doi.org/10.1128/AAC.00416-10
dc.subjectantibiotic therapy
dc.subjectpancreatitis
dc.titleChanges in antibiotic distribution due to pancreatitis
dc.typeJournal article
pubs.publication-statusPublished
ror.mmsid9915909115601831

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