X-ray imaging of tumor growth in live mice by detecting gold-nanoparticle-loaded cells
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Date
2012
Authors
Chien, C.C.
Chen, H.
Lai, S.
Hwu, Y.
Petibois, C.
Yang, C.
Chu, Y.
Margaritondo, G.
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Journal article
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Scientific Reports, 2012; 2(1):1-6
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Abstract
We show that sufficient concentrations of gold nanoparticles produced by an original synthesis method in EMT-6 and CT-26 cancer cells make it possible to detect the presence, necrosis and proliferation of such cells after inoculation in live mice. We first demonstrated that the nanoparticles do not interfere with the proliferation process. Then, we observed significant differences in the tumor evolution and the angiogenesis process after shallow and deep inoculation. A direct comparison with pathology optical images illustrates the effectiveness of this approach
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Data source: Supplementary information, http://www.nature.com/scientificreports
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Copyright 2012 Nature Publishing Group. This work is licensed under a Creative Commons Attribution-Non Commercial-No Derivative Works 3.0 Unported License.