The effects of life experiences and polygenic risk for depression on the development of positive and negative cognitive biases across adolescence: The CogBIAS hypothesis

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dc.contributor.authorZavlis, O.
dc.contributor.authorParsons, S.
dc.contributor.authorFox, E.
dc.contributor.authorBooth, C.
dc.contributor.authorSongco, A.
dc.contributor.authorVincent, J.P.
dc.date.issued2025
dc.descriptionFirst Published online 22 January 2024
dc.description.abstractThe Cognitive Bias (CogBIAS) hypothesis proposes that cognitive biases develop as a function of environmental influences (which determine the valence of biases) and the genetic susceptibility to those influences (which determines the potency of biases). The current study employed a longitudinal, polygenic-by-environment approach to examine the CogBIAS hypothesis. To this end, measures of life experiences and polygenic scores for depression were used to assess the development of memory and interpretation biases in a three-wave sample of adolescents (12-16 years) (N = 337). Using mixed effects modeling, three patterns were revealed. First, positive life experiences (PLEs) were found to diminish negative and enhance positive forms of memory and social interpretation biases. Second, and against expectation, negative life experiences and depression polygenic scores were not associated with any cognitive outcomes, upon adjusting for psychopathology. Finally, and most importantly, the interaction between high polygenic risk and greater PLEs was associated with a stronger positive interpretation bias for social situations. These results provide the first line of polygenic evidence in support of the CogBIAS hypothesis, but also extend this hypothesis by highlighting positive genetic and nuanced environmental influences on the development of cognitive biases across adolescence.
dc.description.statementofresponsibilityOrestis Zavlis, Sam Parsons, Elaine Fox, Charlotte Booth, Annabel Songco and John Paul Vincent
dc.identifier.citationDevelopment and Psychopathology, 2025; 37(1):361-370
dc.identifier.doi10.1017/S0954579423001645
dc.identifier.issn0954-5794
dc.identifier.issn1469-2198
dc.identifier.orcidFox, E. [0000-0002-2464-0462]
dc.identifier.urihttps://hdl.handle.net/2440/140862
dc.language.isoen
dc.publisherCambridge University Press
dc.rights© The Author(s), 2024. Published by Cambridge University Press. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:// creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
dc.source.urihttp://dx.doi.org/10.1017/s0954579423001645
dc.subjectAdolescence
dc.subjectcognitive biases
dc.subjectlife experiences
dc.subjectpolygenic risk scores
dc.subjectpsychopathology
dc.titleThe effects of life experiences and polygenic risk for depression on the development of positive and negative cognitive biases across adolescence: The CogBIAS hypothesis
dc.typeJournal article
pubs.publication-statusPublished

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