Effect of immunization with pneumolysin on survival time of mice challenged with Streptococcus pneumoniae
Date
1983
Authors
Paton, J.
Lock, R.
Hansman, D.
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Journal article
Citation
Infection and Immunity, 1983; 40(2):548-552
Statement of Responsibility
James C. Paton, Robert A. Lock, and David J. Hansman
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Abstract
The role of the cytolytic toxin pneumolysin in the pathogenicity of Streptococcus pneumoniae was investigated. Pneumolysin was purified to homogeneity and used to immunize mice. When these mice were subsequently challenged via the nasal route with virulent S. pneumoniae, they survived significantly longer than control mice. The mean survival times were 5.52 and 2.48 days for immunized and control mice, respectively. This work provides direct evidence for the involvement of pneumolysin in pneumococcal pathogenicity.
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© 1983, American Society for Microbiology