Effect of immunization with pneumolysin on survival time of mice challenged with Streptococcus pneumoniae

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dc.contributor.authorPaton, J.
dc.contributor.authorLock, R.
dc.contributor.authorHansman, D.
dc.date.issued1983
dc.description.abstractThe role of the cytolytic toxin pneumolysin in the pathogenicity of Streptococcus pneumoniae was investigated. Pneumolysin was purified to homogeneity and used to immunize mice. When these mice were subsequently challenged via the nasal route with virulent S. pneumoniae, they survived significantly longer than control mice. The mean survival times were 5.52 and 2.48 days for immunized and control mice, respectively. This work provides direct evidence for the involvement of pneumolysin in pneumococcal pathogenicity.
dc.description.statementofresponsibilityJames C. Paton, Robert A. Lock, and David J. Hansman
dc.identifier.citationInfection and Immunity, 1983; 40(2):548-552
dc.identifier.doi10.1128/iai.40.2.548-552.1983
dc.identifier.issn0019-9567
dc.identifier.issn1098-5522
dc.identifier.orcidPaton, J. [0000-0001-9807-5278]
dc.identifier.urihttp://hdl.handle.net/2440/85785
dc.language.isoen
dc.publisherAmerican Society for Microbiology
dc.rights© 1983, American Society for Microbiology
dc.source.urihttp://iai.asm.org/content/40/2/548
dc.subjectAnimals
dc.subjectMice
dc.subjectStreptococcus pneumoniae
dc.subjectPneumococcal Infections
dc.subjectBacterial Proteins
dc.subjectStreptolysins
dc.subjectAntibodies, Bacterial
dc.subjectImmunization
dc.titleEffect of immunization with pneumolysin on survival time of mice challenged with Streptococcus pneumoniae
dc.typeJournal article
pubs.publication-statusPublished

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