Dietary patterns and β-amyloid deposition in aging Australian women
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2018
Authors
Hill, E.
Clifton, P.
Goodwill, A.M.
Dennerstein, L.
Campbell, S.
Szoeke, C.
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Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2018; 4(1):535-541
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Abstract
Introduction: Evidence indicates that associations between diet and Alzheimer’s disease may occur through biomarker pathways such as amyloid-b (Ab); however, few studies have investigated dietary/Ab relationships, and no study has investigated this relationship in women.
Methods: Dietary patterns were extrapolated for 115 participants from the Women’s Health Aging Project. Aβ deposition was measured via in vivo F-18 florbetaben positron emission tomography scanning.
Results: Participants were, on average, aged 70 years (62.63 SD), had 13 years of education (63.57SD), a BMI of 28 kg/m2 (65.46 SD), and a daily energy intake of 5161 kJ (61679.03 SD). Four dietarypatterns were identified: high fat, Mediterranean, junk food, and low fat. Adherence to the junk food diet was a significant predictor of Aβ deposition (β = .10, P = .03).
Discussion: This study highlights the potential of diet to influence neurodegenerative disease and as a potential modifiable lifestyle risk factor for Alzheimer’s disease.
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Copyright 2018 The Authors This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)