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Dietary patterns and β-amyloid deposition in aging Australian women

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dc.contributor.authorHill, E.
dc.contributor.authorClifton, P.
dc.contributor.authorGoodwill, A.M.
dc.contributor.authorDennerstein, L.
dc.contributor.authorCampbell, S.
dc.contributor.authorSzoeke, C.
dc.date.issued2018
dc.description.abstractIntroduction: Evidence indicates that associations between diet and Alzheimer’s disease may occur through biomarker pathways such as amyloid-b (Ab); however, few studies have investigated dietary/Ab relationships, and no study has investigated this relationship in women. Methods: Dietary patterns were extrapolated for 115 participants from the Women’s Health Aging Project. Aβ deposition was measured via in vivo F-18 florbetaben positron emission tomography scanning. Results: Participants were, on average, aged 70 years (62.63 SD), had 13 years of education (63.57SD), a BMI of 28 kg/m2 (65.46 SD), and a daily energy intake of 5161 kJ (61679.03 SD). Four dietarypatterns were identified: high fat, Mediterranean, junk food, and low fat. Adherence to the junk food diet was a significant predictor of Aβ deposition (β = .10, P = .03). Discussion: This study highlights the potential of diet to influence neurodegenerative disease and as a potential modifiable lifestyle risk factor for Alzheimer’s disease.
dc.identifier.citationAlzheimer’s & Dementia: Translational Research & Clinical Interventions, 2018; 4(1):535-541
dc.identifier.doi10.1016/j.trci.2018.09.007
dc.identifier.issn2352-8737
dc.identifier.issn2352-8737
dc.identifier.orcidClifton, P. [0000-0002-6411-626X]
dc.identifier.urihttps://hdl.handle.net/11541.2/134977
dc.language.isoen
dc.publisherElsevier
dc.rightsCopyright 2018 The Authors This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
dc.source.urihttps://doi.org/10.1016/j.trci.2018.09.007
dc.subjectbiomarkers
dc.subjectAlzheimer’s disease
dc.subjectneuropathology
dc.subjectβ -amyloid protein
dc.subjectdiet
dc.subjectnutrition
dc.subjectdietary pattern
dc.subjectfactor analysis
dc.subjectwomen
dc.titleDietary patterns and β-amyloid deposition in aging Australian women
dc.typeJournal article
pubs.publication-statusPublished
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ror.mmsid9916242311001831

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