Effect of environment and aging on the pulmonary surfactant system
Date
2015
Authors
Orgeig, S.
Morrison, J.
Daniels, C.B.
Editors
Harding, R.
Pinkerton, K.
Pinkerton, K.
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Book chapter
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Source details - Title: The lung: development, aging and the enivronment, 2015 / Harding, R., Pinkerton, K. (ed./s), pp.447-470
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Abstract
The central role played by the pulmonary surfactant system in the healthy functioning of the lung is evidenced by the diverse range of environmental factors that can affect the system throughout fetal, neonatal, and adult life and in the aging lung. During development, for example, changes in nutrition and oxygenation as well as chemicals and agents that are transferred from the maternal circulation via the placenta may impact upon the surfactant system. Frequently, the consequences of these early insults persist into the neonatal and adult periods. The adult and aging surfactant system is also sensitive to changes in oxygenation and exposure to a range of gaseous and particulate pollutants. Abnormalities involve changes in the immune and redox status of the lung, which may lead to inflammatory and oxidative damage of surfactant lipids and proteins, as well as increased alveolar permeability, which result in perturbations including reduced surface activity and hence lung compliance, pulmonary edema, and surfactant inactivation.
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Copyright 2015 Elsevier