Current studentsExisting staffContact us
 

Effect of environment and aging on the pulmonary surfactant system

Simple item page
dc.contributor.authorOrgeig, S.
dc.contributor.authorMorrison, J.
dc.contributor.authorDaniels, C.B.
dc.contributor.editorHarding, R.
dc.contributor.editorPinkerton, K.
dc.date.issued2015
dc.description.abstractThe central role played by the pulmonary surfactant system in the healthy functioning of the lung is evidenced by the diverse range of environmental factors that can affect the system throughout fetal, neonatal, and adult life and in the aging lung. During development, for example, changes in nutrition and oxygenation as well as chemicals and agents that are transferred from the maternal circulation via the placenta may impact upon the surfactant system. Frequently, the consequences of these early insults persist into the neonatal and adult periods. The adult and aging surfactant system is also sensitive to changes in oxygenation and exposure to a range of gaseous and particulate pollutants. Abnormalities involve changes in the immune and redox status of the lung, which may lead to inflammatory and oxidative damage of surfactant lipids and proteins, as well as increased alveolar permeability, which result in perturbations including reduced surface activity and hence lung compliance, pulmonary edema, and surfactant inactivation.
dc.identifier.citationSource details - Title: The lung: development, aging and the enivronment, 2015 / Harding, R., Pinkerton, K. (ed./s), pp.447-470
dc.identifier.doi10.1016/B978-0-12-799941-8.00026-2
dc.identifier.isbn9780127999418
dc.identifier.urihttps://hdl.handle.net/1959.8/162956
dc.language.isoen
dc.publisherAcademic Press
dc.publisher.placeAmsterdam
dc.rightsCopyright 2015 Elsevier
dc.source.urihttps://doi.org/10.1016/B978-0-12-799941-8.00026-2
dc.titleEffect of environment and aging on the pulmonary surfactant system
dc.typeBook chapter
pubs.publication-statusPublished
ror.mmsid9915910253501831

Files

Collections