Relation of Socioeconomic Position with Ankle-Brachial Index

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dc.contributor.authorAgha, G.
dc.contributor.authorMurabito, J.
dc.contributor.authorLynch, J.
dc.contributor.authorAbrahamowicz, M.
dc.contributor.authorHarper, S.
dc.contributor.authorLoucks, E.
dc.date.issued2011
dc.description.abstractPotential upstream determinants of coronary heart disease (CHD) include life-course socioeconomic position (e.g., childhood socioeconomic circumstances, own education and occupation); however, several plausible biological mechanisms by which socioeconomic position (SEP) may influence CHD are poorly understood. Several CHD risk factors appear to be more strongly associated with SEP in women than in men; little is known as to whether any CHD risk factors may be more strongly associated with SEP in men. Objectives were to evaluate whether cumulative life-course SEP is associated with a measurement of subclinical atherosclerosis, the ankle-brachial index (ABI), in men and women. This study was a prospective analysis of 1,454 participants from the Framingham Heart Study Offspring Cohort (mean age 57 years, 53.8% women). Cumulative SEP was calculated by summing tertile scores for father's education, own education, and own occupation. ABI was dichotomized as low (≤1.1) and normal (>1.1 to 1.4). After adjustment for age and CHD risk factors cumulative life-course SEP was associated with low ABI in men (odds ratio [OR] 2.04, 95% confidence interval [CI] 1.22 to 3.42, for low vs high cumulative SEP score) but not in women (OR 0.86, 95% CI 0.56 to 1.33). Associations with low ABI in men were substantially driven by their own education (OR 4.13, 95% CI 1.86 to 9.16, for lower vs higher than high school education). In conclusion, cumulative life-course SEP was associated with low ABI in men but not in women.
dc.description.statementofresponsibilityGolareh Agha, Joanne M. Murabito, John W. Lynch, Michal Abrahamowicz, Sam B. Harper and Eric B. Loucks
dc.identifier.citationAmerican Journal of Cardiology, 2011; 108(11):1651-1657
dc.identifier.doi10.1016/j.amjcard.2011.07.030
dc.identifier.issn0002-9149
dc.identifier.issn1879-1913
dc.identifier.orcidLynch, J. [0000-0003-2781-7902]
dc.identifier.urihttp://hdl.handle.net/2440/71565
dc.language.isoen
dc.publisherExcerpta Medica Inc
dc.rights© 2011 Elsevier Inc. All rights reserved.
dc.source.urihttps://doi.org/10.1016/j.amjcard.2011.07.030
dc.subjectHumans
dc.subjectCoronary Disease
dc.subjectPrognosis
dc.subjectMorbidity
dc.subjectSurvival Rate
dc.subjectRetrospective Studies
dc.subjectFollow-Up Studies
dc.subjectBlood Pressure
dc.subjectSocial Class
dc.subjectSocioeconomic Factors
dc.subjectAdult
dc.subjectMiddle Aged
dc.subjectUnited States
dc.subjectEurope
dc.subjectFemale
dc.subjectMale
dc.subjectAtherosclerosis
dc.subjectAnkle Brachial Index
dc.titleRelation of Socioeconomic Position with Ankle-Brachial Index
dc.typeJournal article
pubs.publication-statusPublished

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