In vivo activity of benzoyl ester clerodane diterpenoid derivatives from Dodonaea polyandra

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dc.contributor.authorSimpson, B.
dc.contributor.authorClaudie, D.
dc.contributor.authorGerber, J.
dc.contributor.authorPyke, S.
dc.contributor.authorWang, J.
dc.contributor.authorMcKinnon, R.
dc.contributor.authorSemple, S.
dc.date.issued2011
dc.description.abstractFour new benzoyl ester clerodane diterpenoids, 15,16-epoxy-8α-(benzoyloxy)methylcleroda-3,13(16),14-trien-18-oic acid (1), 15,16-epoxy-8α-(benzoyloxy)methyl-2α-hydroxycleroda-3,13(16),14-trien-18-oic acid (2), 15,16-epoxy-8α-(benzoyloxy)methyl-2-oxocleroda-3,13(16),14-trien-18-oic acid (3), and 15,16-epoxy-2α-benzoyloxycleroda-3,13(16),14-trien-18-oic acid (4), have been isolated from the leaves and stems of Dodonaea polyandra. The anti-inflammatory activities of compounds 1, 2, and 4 were evaluated by means of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema. Compounds 2 and 4 exhibited maximum inhibition of inflammation (70-76%) at doses of 0.22 and 0.9 μmol/ear, respectively. Modest activity (~45% inhibition) was maintained at nanomole/ear doses.
dc.description.statementofresponsibilityBradley S. Simpson, David J. Claudie, Jacobus P. Gerber, Simon M. Pyke, Jiping Wang, Ross A. McKinnon and Susan J. Semple
dc.identifier.citationJournal of Natural Products, 2011; 74(4):650-657
dc.identifier.doi10.1021/np100701s
dc.identifier.issn0163-3864
dc.identifier.issn1520-6025
dc.identifier.orcidPyke, S. [0000-0002-0061-5115]
dc.identifier.urihttp://hdl.handle.net/2440/66953
dc.language.isoen
dc.publisherAmer Chemical Soc
dc.relation.grantARC
dc.rightsCopyright © 2011 The American Chemical Society and American Society of Pharmacognosy
dc.source.urihttps://doi.org/10.1021/np100701s
dc.subjectEar
dc.subjectAnimals
dc.subjectMice
dc.subjectSapindaceae
dc.subjectPlant Leaves
dc.subjectPlant Stems
dc.subjectDisease Models, Animal
dc.subjectEdema
dc.subjectDiterpenes, Clerodane
dc.subjectTetradecanoylphorbol Acetate
dc.subjectAnti-Inflammatory Agents, Non-Steroidal
dc.subjectMolecular Structure
dc.subjectAustralia
dc.titleIn vivo activity of benzoyl ester clerodane diterpenoid derivatives from Dodonaea polyandra
dc.typeJournal article
pubs.publication-statusPublished

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