Contribution of membrane receptor signalling to chronic visceral pain

Date

2018

Authors

Sadeghi, M.
Erickson, A.
Castro, J.
Deiteren, A.
Harrington, A.
Grundy, L.
Adams, D.
Brierley, S.

Editors

Advisors

Journal Title

Journal ISSN

Volume Title

Type:

Journal article

Citation

The International Journal of Biochemistry and Cell Biology, 2018; 98:10-23

Statement of Responsibility

Mahsa Sadeghi, Andelain Erickson, Joel Castro, Annemie Deiteren, Andrea M. Harrington, Luke Grundy, David J. Adams, Stuart M. Brierley

Conference Name

DOI

10.1016/j.biocel.2018.02.017

Abstract

Irritable bowel syndrome and inflammatory bowel disease are major forms of chronic visceral pain, which affect over 15% of the global population. In order to identify new therapies, it is important to understand the underlying causes of chronic visceral pain. This review provides recent evidence demonstrating that inflammation or infection of the gastrointestinal tract triggers specific changes in the neuronal excitability of sensory pathways responsible for the transmission of nociceptive information from the periphery to the central nervous system. Specific changes in the expression and function of a variety of ion channels and receptors have been documented in inflammatory and chronic visceral pain conditions relevant to irritable bowel syndrome and inflammatory bowel disease. An increase in pro-nociceptive mechanisms enhances peripheral drive from the viscera and provides an underlying basis for enhanced nociceptive signalling during chronic visceral pain states. Recent evidence also highlights increases in anti-nociceptive mechanisms in models of chronic visceral pain, which present novel targets for pharmacological treatment of this condition.

School/Discipline

Dissertation Note

Provenance

Description

Access Status

Rights

© 2018 Elsevier Ltd. All rights reserved.

License

Grant ID

http://purl.org/au-research/grants/nhmrc/1126378
 http://purl.org/au-research/grants/nhmrc/1083480
 http://purl.org/au-research/grants/nhmrc/1139366
 http://purl.org/au-research/grants/nhmrc/1140297
 http://purl.org/au-research/grants/arc/DE130100223
 http://purl.org/au-research/grants/arc/DP180101395
 http://purl.org/au-research/grants/nhmrc/1072113

Published Version

https://doi.org/10.1016/j.biocel.2018.02.017

Call number

Persistent link to this record

http://hdl.handle.net/2440/112780