Contribution of membrane receptor signalling to chronic visceral pain

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dc.contributor.authorSadeghi, M.
dc.contributor.authorErickson, A.
dc.contributor.authorCastro, J.
dc.contributor.authorDeiteren, A.
dc.contributor.authorHarrington, A.
dc.contributor.authorGrundy, L.
dc.contributor.authorAdams, D.
dc.contributor.authorBrierley, S.
dc.date.issued2018
dc.description.abstractIrritable bowel syndrome and inflammatory bowel disease are major forms of chronic visceral pain, which affect over 15% of the global population. In order to identify new therapies, it is important to understand the underlying causes of chronic visceral pain. This review provides recent evidence demonstrating that inflammation or infection of the gastrointestinal tract triggers specific changes in the neuronal excitability of sensory pathways responsible for the transmission of nociceptive information from the periphery to the central nervous system. Specific changes in the expression and function of a variety of ion channels and receptors have been documented in inflammatory and chronic visceral pain conditions relevant to irritable bowel syndrome and inflammatory bowel disease. An increase in pro-nociceptive mechanisms enhances peripheral drive from the viscera and provides an underlying basis for enhanced nociceptive signalling during chronic visceral pain states. Recent evidence also highlights increases in anti-nociceptive mechanisms in models of chronic visceral pain, which present novel targets for pharmacological treatment of this condition.
dc.description.statementofresponsibilityMahsa Sadeghi, Andelain Erickson, Joel Castro, Annemie Deiteren, Andrea M. Harrington, Luke Grundy, David J. Adams, Stuart M. Brierley
dc.identifier.citationThe International Journal of Biochemistry and Cell Biology, 2018; 98:10-23
dc.identifier.doi10.1016/j.biocel.2018.02.017
dc.identifier.issn1357-2725
dc.identifier.issn1878-5875
dc.identifier.orcidCastro, J. [0000-0002-5781-2224]
dc.identifier.orcidHarrington, A. [0000-0002-1562-4137]
dc.identifier.orcidGrundy, L. [0000-0002-3900-7141]
dc.identifier.orcidBrierley, S. [0000-0002-2527-2905]
dc.identifier.urihttp://hdl.handle.net/2440/112780
dc.language.isoen
dc.publisherElsevier
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1126378
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1083480
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1139366
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1140297
dc.relation.granthttp://purl.org/au-research/grants/arc/DE130100223
dc.relation.granthttp://purl.org/au-research/grants/arc/DP180101395
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1072113
dc.rights© 2018 Elsevier Ltd. All rights reserved.
dc.source.urihttps://doi.org/10.1016/j.biocel.2018.02.017
dc.subjectAfferents
dc.subjectColon
dc.subjectIon channels
dc.subjectNociception
dc.subjectPain
dc.titleContribution of membrane receptor signalling to chronic visceral pain
dc.typeJournal article
pubs.publication-statusPublished

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