Coumarin amphiphiles as membrane-active antibacterial agents /
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(Published version)
Date
2025
Authors
Nitschke, Samuel O.
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Type:
thesis
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Abstract
We are not alone. Life as we know it is an unending battle for energy and resources between the organisms that inhabit the Earth. Bacteria are microscopic organisms that are capable of outcompeting humans for these resources, resulting in disease. As humans have evolved with bacteria, technological advancements have resulted in the ability to manufacture an artillery of exogenous chemical compounds that are capable of selectively killing these microorganisms. Bacteria have also evolved and developed mechanisms that render these chemical compounds, otherwise known as antibiotics, ineffective. The continual development of new antibiotics is required to ensure humans maintain a heavily stocked arsenal of chemical compounds that can compete with these microorganisms. This project focuses on the development of novel antibacterial agents that can hinder the development of resistance in bacteria.
School/Discipline
University of South Australia. UniSA Clinical and Health Sciences.
UniSA Clinical and Health Sciences
UniSA Clinical and Health Sciences
Dissertation Note
Thesis (PhD(Pharmaceutical Science))--University of South Australia, 2025.
Provenance
Copyright 2025 Samuel O. Nitschke.
Description
1 ethesis (xxxix, 440 pages) :
colour illustrations, colour charts.
Includes bibliographical references (pages 362-389)
colour illustrations, colour charts.
Includes bibliographical references (pages 362-389)
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506 0#$fstar $2Unrestricted online access