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Coumarin amphiphiles as membrane-active antibacterial agents /

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dc.contributor.authorNitschke, Samuel O.
dc.contributor.schoolUniversity of South Australia. UniSA Clinical and Health Sciences.
dc.contributor.schoolUniSA Clinical and Health Sciences
dc.date.issued2025
dc.description1 ethesis (xxxix, 440 pages) :
dc.descriptioncolour illustrations, colour charts.
dc.descriptionIncludes bibliographical references (pages 362-389)
dc.description.abstractWe are not alone. Life as we know it is an unending battle for energy and resources between the organisms that inhabit the Earth. Bacteria are microscopic organisms that are capable of outcompeting humans for these resources, resulting in disease. As humans have evolved with bacteria, technological advancements have resulted in the ability to manufacture an artillery of exogenous chemical compounds that are capable of selectively killing these microorganisms. Bacteria have also evolved and developed mechanisms that render these chemical compounds, otherwise known as antibiotics, ineffective. The continual development of new antibiotics is required to ensure humans maintain a heavily stocked arsenal of chemical compounds that can compete with these microorganisms. This project focuses on the development of novel antibacterial agents that can hinder the development of resistance in bacteria.
dc.description.dissertationThesis (PhD(Pharmaceutical Science))--University of South Australia, 2025.
dc.identifier.urihttps://hdl.handle.net/11541.2/43721
dc.language.isoen
dc.provenanceCopyright 2025 Samuel O. Nitschke.
dc.subjectcoumarin;cationic antimicrobial peptides;antimicrobial
dc.subject.lcshAnti-infective agents
dc.subject.lcshAntibacterial agents
dc.subject.lcshBacterial infections
dc.titleCoumarin amphiphiles as membrane-active antibacterial agents /
dc.typethesis
dcterms.accessRights506 0#$fstar $2Unrestricted online access
ror.fileinfo12304157110001831 13304157100001831 Nitschke, Samuel - Thesis
ror.mmsid9917045466801831

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