Advances in Skin Tissue Bioengineering and the Challenges of Clinical Translation

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dc.contributor.authorDearman, B.L.
dc.contributor.authorBoyce, S.T.
dc.contributor.authorGreenwood, J.E.
dc.date.issued2021
dc.description.abstractSkin tissue bioengineering is an emerging field that brings together interdisciplinary teams to promote successful translation to clinical care. Extensive deep tissue injuries, such as large burns and other major skin loss conditions, are medical indications where bioengineered skin substitutes (that restore both dermal and epidermal tissues) are being studied as alternatives. These may not only reduce mortality but also lessen morbidity to improve quality of life and functional outcome compared with the current standards of care. A common objective of dermal-epidermal therapies is to reduce the time required to accomplish stable closure of wounds with minimal scar in patients with insufficient donor sites for autologous split-thickness skin grafts. However, no commercially-available product has yet fully satisfied this objective. Tissue engineered skin may include cells, biopolymer scaffolds and drugs, and requires regulatory review to demonstrate safety and efficacy. They must be scalable for manufacturing and distribution. The advancement of technology and the introduction of bioreactors and bio-printing for skin tissue engineering may facilitate clinical products’ availability. This mini-review elucidates the reasons for the few available commercial skin substitutes. In addition, it provides insights into the challenges faced by surgeons and scientists to develop new therapies and deliver the results of translational research to improve patient care.
dc.description.statementofresponsibilityBronwyn L. Dearman, Steven T. Boyce, and John E. Greenwood
dc.identifier.citationFrontiers in Surgery, 2021; 8:640879-1-640879-10
dc.identifier.doi10.3389/fsurg.2021.640879
dc.identifier.issn2296-875X
dc.identifier.issn2296-875X
dc.identifier.orcidDearman, B.L. [0000-0001-8804-8401]
dc.identifier.urihttps://hdl.handle.net/2440/146015
dc.language.isoen
dc.publisherFrontiers Media SA
dc.rights© 2021 Dearman, Boyce and Greenwood. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.source.urihttps://doi.org/10.3389/fsurg.2021.640879
dc.subjectskin; bioengineering; burns; wound closure; skin substitutes; clinical translation; tissue engineering; biopolymers
dc.titleAdvances in Skin Tissue Bioengineering and the Challenges of Clinical Translation
dc.typeJournal article
pubs.publication-statusPublished

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