Diagnostic and prognostic significance of circulating secreted frizzled-related protein 5 in colorectal cancer
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Date
2024
Authors
Li, R.
Liu, S.
Yeo, K.
Edwards, S.
Li, M.Y.
Santos, R.
Rad, S.K.
Wu, F.
Maddern, G.
Young, J.
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Journal article
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Cancer Medicine, 2024; 13(11):e7352-1-e7352-11
Statement of Responsibility
Runhao Li, Saifei Liu, Kenny Yeo, Suzanne Edwards, Man Ying Li, Ryan Santos, Sima Kianpour Rad, Fangmeinuo Wu, Guy Maddern, Joanne Young, Yoko Tomita, Amanda Townsend, Kevin Fenix, Ehud Hauben, Timothy Price, Eric Smith
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Abstract
Background: Secreted Frizzled-Related Protein 5 (SFRP5) modulates Wnt signalling pathways, affecting diverse biological processes. We assessed the diagnostic and prognostic value of circulating SFRP5 (cSFRP5) in colorectal cancer (CRC) Methods: Plasma cSFRP5 concentrations were measured using enzyme-linked immunosorbent assay (ELISA) in healthy donors (n=133), individuals diagnosed with CRC (n=449), colorectal polyps (n=85), and medical conditions in other organs including cancer, inflammation, and benign states (n=64). Results: Patients with CRC, polyps, and other conditions showed higher cSFRP5 levels than healthy individuals (p<0.0001). Receiver operating characteristic curves comparing healthy donors with medical conditions, polyps and CRC were 0.814 (p<0.0001), 0.763 (p<0.0001) and 0.762 (p<0.0001), respectively. In CRC, cSFRP5 correlated with patient age (p<0.0001), tumour stage (p<0.0001), and histological differentiation (p=0.0273). Levels, adjusted for patient age, sex, plasma age and collection institution, peaked in stage II versus I (p<0.0001), III (p=0.0002) and IV (p<0.0001), were lowest in stage I versus III (p=0.0002) and IV (p=0.0413), with no difference between stage III and IV. Elevated cSFRP5 levels predicted longer overall survival in stages II-III CRC (univariate: HR 1.82, 95% CI: 1.02–3.26, p=0.024; multivariable: HR 2.34, 95% CI: 1.12–4.88, p=0.015). Conclusion: This study confirms cSFRP5 levels are elevated in CRC compared to healthy control and reveals a correlation between elevated cSFRP5 and overall survival in stages II-III disease.
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© 2024 The Author(s). Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.