Current studentsExisting staffContact us
 

Risk of a first clinical diagnosis of central nervous system demyelination in relation to human herpesviruses in the context of Epstein–Barr virus

Simple item page
dc.contributor.authorLucas, R.M.
dc.contributor.authorLay, M.L.J.
dc.contributor.authorGrant, J.
dc.contributor.authorCherbuin, N.
dc.contributor.authorToi, C.S.
dc.contributor.authorDear, K.
dc.contributor.authorTaylor, B.V.
dc.contributor.authorDwyer, D.E.
dc.contributor.authorChapman, C.
dc.contributor.authorCoulthard, A.
dc.contributor.authorDear, K.
dc.contributor.authorDwyer, T.
dc.contributor.authorKilpatrick, T.
dc.contributor.authorLucas, R.
dc.contributor.authorMcMichael, T.
dc.contributor.authorPonsonby, A.L.
dc.contributor.authorTaylor, B.
dc.contributor.authorValery, P.
dc.contributor.authorvan der Mei, I.
dc.contributor.authorWilliams, D.
dc.contributor.authoret al.
dc.date.issued2023
dc.descriptionPublished September 2023
dc.description.abstractBackground and purpose: Epstein–Barr virus (EBV) is implicated in multiple sclerosis (MS) risk; evidence for other herpesviruses is inconsistent. Here, we test blood markers of infection with human herpesvirus 6 (HHV-6), varicella zoster virus (VZV), and cytomegalovirus (CMV) as risk factors for a first clinical diagnosis of central nervous system demyelination (FCD) in the context of markers of EBV infection. Methods: In the Ausimmune case–control study, cases had an FCD, and population controls were matched on age, sex, and study region. We quantified HHV-6- and VZVDNA load in whole blood and HHV-6, VZV, and CMV antibodies in serum. Conditional logistic regression tested associations with FCD risk, adjusting for Epstein–Barr nuclear antigen (EBNA) IgG, EBV-DNA load, and other covariates. Results: In 204 FCD cases and 215 matched controls, only HHV-6-DNA load (positive vs. negative) was associated with FCD risk (adjusted odds ratio = 2.20, 95% confidence interval = 1.08–4.46, p= 0.03). Only EBNA IgG and HHV-6-DNA positivity were retained in a predictive model of FCD risk; the combination had a stronger association than either alone. CMV-specific IgG concentration modified the association between an MS riskrelated human leucocyte antigen gene and FCD risk. Six cases and one control had very high HHV-6-DNA load (>1.0 × 106 copies/mL). Conclusions: HHV-6-DNA positivity and high load (possibly due to inherited HHV-6 chromosomal integration) were associated with increased FCD risk, particularly in association with markers of EBV infection. With growing interest in prevention/ management of MS through EBV-related pathways, there should be additional consideration of the role of HHV-6 infection.
dc.description.statementofresponsibilityRobyn M. Lucas, Meav-Lang J. Lay, James Grant, Nicolas Cherbuin, Cheryl S. Toi, Keith Dear, Bruce V. Taylor, Dominic E. Dwyer, Ausimmune Investigator Group, Anne-Louise Ponsonby
dc.identifier.citationEuropean Journal of Neurology, 2023; 30(9):2752-2760
dc.identifier.doi10.1111/ene.15919
dc.identifier.issn1351-5101
dc.identifier.issn1468-1331
dc.identifier.orcidDear, K. [0000-0002-0788-7404]
dc.identifier.urihttps://hdl.handle.net/2440/139035
dc.language.isoen
dc.publisherWiley
dc.relation.grantNHMRC
dc.rights© 2023 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
dc.source.urihttps://doi.org/10.1111/ene.15919
dc.subjectcase–control; human herpesviruses; multiple sclerosis; viral infections
dc.titleRisk of a first clinical diagnosis of central nervous system demyelination in relation to human herpesviruses in the context of Epstein–Barr virus
dc.typeJournal article
pubs.publication-statusPublished online

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
hdl_139035.pdf
Size:
704.57 KB
Format:
Adobe Portable Document Format
Description:
Published version
Download

Collections

Public Health publications