Method of purifying RNA binding protein-RNA complexes

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dc.contributor.assigneeDarnell Robert, Jensen Kirk, Ule Jernej
dc.contributor.authorDarnell, R.
dc.contributor.authorJensen, K.
dc.contributor.authorUle, J.
dc.contributor.otherEitan, Pearl, Latzer & Cohen Zedek LLP,
dc.date.issued2005
dc.descriptionPriority date Oct 23, 2003 Filing date Jul 27, 2009 Application Date: 25.10.2004 Publication Date: 13.10.2005 Publication number US20110076676 A1 Publication type Application Application number US 12/509,856 Publication date Mar 31, 2011
dc.description.abstractThe present invention provides methods for purifying RNA molecules interacting with an RNA binding protein (RBP), and the use of such methods to analyze a gene expression profile of a cell. The invention also provides sequences of RNA molecules that mediate binding to an RBP, proteins encoded by the sequences, a method of identifying the sequences, and the use of the sequences in a screen to identify bioactive molecules. The invention also provides RNA motifs found among the sequences and compounds that bind the RNA motifs. In addition, the invention provides methods of treating diseases associated with a function of an RNA binding protein.
dc.description.statementofresponsibilityInventors: Darnell Robert, Jensen Kirk, Ule Jernej; Assignee: Darnell Robert, Jensen Kirk, Ule Jernej; Agents: Eitan, Pearl, Latzer & Cohen Zedek LLP
dc.identifier.orcidJensen, K. [0000-0002-2084-1734]
dc.identifier.patentUS20050227251 A1
dc.identifier.urihttp://hdl.handle.net/2440/87862
dc.language.isoen
dc.titleMethod of purifying RNA binding protein-RNA complexes
dc.typePatent
pubs.publication-statusPublished

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