Magnetic Nanocomposite Hydrogels for Directing Myofibroblast Activity in Adipose-Derived Stem Cells
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(Published version)
Date
2021
Authors
Islam, M.S.
Molley, T.G.
Ireland, J.
Kruzic, J.J.
Kilian, K.A.
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Journal article
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Advanced NanoBiomed Research, 2021; 1(4):2000072-1-2000072-8
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Md Shariful Islam, Thomas G. Molley, Jake Ireland, Jamie J. Kruzic, and Kristopher A. Kilian
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Abstract
Dynamic cell-culture materials that can change mechanical properties in response to extrinsic stimuli are emerging as promising tools for cell and tissue engineering research. However, most of these techniques involve a one-way stiffening or softening through changes in the materials chemistry, which does not allow reversibility. Here, the incorporation of superparamagnetic iron-oxide nanoparticles within poly(ethylene glycol) hydrogels as dynamic cell culture materials is demonstrated. Using simple permanent magnets and adiposederived stem cells, a near twofold increase in cell spread area and an accompanying 20% enrichment in cells expressing alpha-smooth muscle actin is seen. This platform provides a means to study relationships between dynamic stiffening and cell behavior, using permanent magnets and clinically viable composite materials, with scope for use as a tool to enrich the myofibroblast population in stromal cells.
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© 2021 The Authors. Advanced NanoBiomed Research published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.