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A Gut Instinct on Leukaemia: A New Mechanistic Hypothesis for Microbiota-Immune Crosstalk in Disease Progression and Relapse

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dc.contributor.authorPagani, I.S.
dc.contributor.authorPoudel, G.
dc.contributor.authorWardill, H.R.
dc.date.issued2022
dc.description.abstractDespite significant advances in the treatment of Chronic Myeloid and Acute Lymphoblastic Leukaemia (CML and ALL, respectively), disease progression and relapse remain a major problem. Growing evidence indicates the loss of immune surveillance of residual leukaemic cells as one of the main contributors to disease recurrence and relapse. More recently, there was an appreciation for how the host’s gut microbiota predisposes to relapse given its potent immunomodulatory capacity. This is especially compelling in haematological malignancies where changes in the gut microbiota have been identified after treatment, persisting in some patients for years after the completion of treatment. In this hypothesis-generating review, we discuss the interaction between the gut microbiota and treatment responses, and its capacity to influence the risk of relapse in both CML and ALLWe hypothesize that the gut microbiota contributes to the creation of an immunosuppressive microenvironment, which promotes tumour progression and relapse.
dc.description.statementofresponsibilityIlaria S. Pagani, Govinda Poudel, and Hannah R. Wardill
dc.identifier.citationMicroorganisms, 2022; 10(4):713-1-713-14
dc.identifier.doi10.3390/microorganisms10040713
dc.identifier.issn2076-2607
dc.identifier.issn2076-2607
dc.identifier.orcidPagani, I.S. [0000-0002-3216-2966]
dc.identifier.orcidPoudel, G. [0000-0001-5148-9190]
dc.identifier.orcidWardill, H.R. [0000-0002-6613-3661]
dc.identifier.urihttps://hdl.handle.net/2440/145526
dc.language.isoen
dc.publisherMDPI AG
dc.rights© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
dc.source.urihttps://doi.org/10.3390/microorganisms10040713
dc.subjectgut microbiota; dysbiosis; chronic myeloid leukaemia; acute lymphoblastic leukaemia; disease progression; cancer relapse; immune suppressors; gut metabolites
dc.titleA Gut Instinct on Leukaemia: A New Mechanistic Hypothesis for Microbiota-Immune Crosstalk in Disease Progression and Relapse
dc.typeJournal article
pubs.publication-statusPublished

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