Cortical Plasticity and Interneuron Recruitment in Adolescents Born to Women with Gestational Diabetes Mellitus

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dc.contributor.authorVan Dam, J.M.
dc.contributor.authorGoldsworthy, M.R.
dc.contributor.authorHague, W.M.
dc.contributor.authorCoat, S.
dc.contributor.authorPitcher, J.B.
dc.date.issued2021
dc.description.abstractExposure to gestational diabetes mellitus (GDM) in utero is associated with a range of adverse cognitive and neurological outcomes. Previously, we reported altered neuroplastic responses to continuous theta burst stimulation (cTBS) in GDM-exposed adolescents. Recent research suggests that the relative excitability of complex oligosynaptic circuits (late I-wave circuits) can predict these responses. We aimed to determine if altered I-wave recruitment was associated with neuroplastic responses in adolescents born to women with GDM. A total of 20 GDM-exposed adolescents and 10 controls (aged 13.1 ± 1.0 years) participated. cTBS was used to induce neuroplasticity. I-wave recruitment was assessed by comparing motor-evoked potential latencies using different TMS coil directions. Recruitment of late I-waves was associated with stronger LTD-like neuroplastic responses to cTBS (p = < 0.001, R² = 0.36). There were no differences between groups in mean neuroplasticity (p = 0.37), I-wave recruitment (p = 0.87), or the association between these variables (p = 0.41). The relationship between I-wave recruitment and the response to cTBS previously observed in adults is also present in adolescents and does not appear to be altered significantly by in utero GDM exposure. Exposure to GDM does not appear to significantly impair LTD-like synaptic plasticity or interneuron recruitment.
dc.description.statementofresponsibilityJago M. Van Dam, Mitchell R. Goldsworthy, William M. Hague, Suzette Coat, and Julia B. Pitcher
dc.identifier.citationBrain Sciences, 2021; 11(3):388-1-388-12
dc.identifier.doi10.3390/brainsci11030388
dc.identifier.issn2076-3425
dc.identifier.issn2076-3425
dc.identifier.orcidVan Dam, J.M. [0000-0001-6181-417X]
dc.identifier.orcidGoldsworthy, M.R. [0000-0002-0688-9475]
dc.identifier.orcidHague, W.M. [0000-0002-5355-2955]
dc.identifier.orcidCoat, S. [0000-0002-3836-2854]
dc.identifier.orcidPitcher, J.B. [0000-0002-9648-7540]
dc.identifier.urihttps://hdl.handle.net/2440/145886
dc.language.isoen
dc.publisherMDPI AG
dc.rights© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
dc.source.urihttps://doi.org/10.3390/brainsci11030388
dc.subjectgestational diabetes; transcranial magnetic stimulation; cortisol; neuroplasticity; I-waves; neurodevelopment
dc.titleCortical Plasticity and Interneuron Recruitment in Adolescents Born to Women with Gestational Diabetes Mellitus
dc.typeJournal article
pubs.publication-statusPublished

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