Halide-triggered assembly and selective bisulfate recognition in a quadruply interlocked coordination cage
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2024
Authors
Virtue, J.I.
Tsoukatos, S.
Johnston, M.R.
Bloch, W.M.
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Chemical Science, 2024; 15(45):19119-1-19119-7
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Jemma I. Virtue, Steven Tsoukatos, Martin R. Johnston and Witold M. Bloch
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Abstract
Interlocked coordination cages are a class of multi-cavity architectures with applications in selective anion recognition, adaptive sensing, and catalysis. Controlling the partitioning of their cavities through ligand design and appropriate anion templates is critical to their guest binding scope, yet remains a challenge. Here, we present a thermodynamically stable [Pd2L4](BF4)4 cage assembled from a bis-monodentate ligand featuring a non-coordinating bis-pyrazole methane backbone. As a result of its idealized dimensions, NMR, ESI-MS, and X-ray analyses reveal that halides can trigger the interpenetration of this cage into a [X@Pd4L8]7+ dimer (X = Cl- or Br-) where the halide template resides only in the central pocket. The anion-cation pattern of this interlocked host facilitates exceptional binding affinity for the bisulfate anion in its two outer pockets (up to 106 M-1 in MeCN), strongly outcompeting other tetrahedral anions of similar size.
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© 2024 The Author(s). Published by the Royal Society of Chemistry. Open Access. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.