Cholecystectomy is associated with dysglycaemia: cross-sectional and prospective analyses.

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dc.contributor.authorSang, M.
dc.contributor.authorXie, C.
dc.contributor.authorQiu, S.
dc.contributor.authorWang, X.
dc.contributor.authorHorowitz, M.
dc.contributor.authorJones, K.L.
dc.contributor.authorRayner, C.K.
dc.contributor.authorSun, Z.
dc.contributor.authorWu, T.
dc.date.issued2022
dc.description.abstractCholecystectomy has been reported to be associated with increased risk of diabetes in cross‐sectional studies. In the current study, we performed both cross‐sectional and prospective analyses to examine the association between cholecystectomy and dysglycaemia in Chinese community‐dwelling adults. A total of 1612 participants (n = 1564 without cholecystectomy and n = 48 with cholecystectomy) were evaluated for glycaemic status (according to the World Health Organization (WHO) 1999 criteria) and then followed up over ~3.2 years. Percent changes (Δ) in fasting blood glucose and HbA1c from baseline at the follow‐up visit were calculated to define glycaemic control as stable (−10%≤ Δ < 10%), improved (Δ < −10%), or worsened (Δ ≥ 10%). The baseline cross‐sectional analyses indicated that cholecystectomy was associated with an increased risk of both prediabetes and diabetes, while the prospective analysis indicated that cholecystectomy was also associated with a greater risk of deterioration in glycaemic control (ΔFPG ≥10% and ΔHbA1c ≥10%) (P < 0.05 for each, both before and after adjusting for potential confounding covariates). These observations suggest that individuals in the Chinese community‐dwelling population who have undergone cholecystectomy are at increased risk of dysglycaemia. Further studies are warranted to both delineate the underlying mechanisms and to clarify whether more intense surveillance for future development of diabetes is needed in this group.
dc.description.statementofresponsibilityMiaomiao Sang, Cong Xie, Shanhu Qiu, Xuyi Wang, Michael Horowitz, Karen L. Jones, Christopher K. Rayner, Zilin Sun, Tongzhi Wu
dc.identifier.citationDiabetes, Obesity and Metabolism, 2022; 24(8):1656-1660
dc.identifier.doi10.1111/dom.14730
dc.identifier.issn1462-8902
dc.identifier.issn1463-1326
dc.identifier.orcidXie, C. [0000-0002-0054-9269]
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]
dc.identifier.orcidJones, K.L. [0000-0002-1155-5816]
dc.identifier.orcidRayner, C.K. [0000-0002-5527-256X]
dc.identifier.orcidWu, T. [0000-0003-1656-9210]
dc.identifier.urihttps://hdl.handle.net/2440/145885
dc.language.isoen
dc.publisherWiley
dc.rights© 2022 The Authors. Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
dc.source.urihttps://doi.org/10.1111/dom.14730
dc.subjectcohort study; glycaemic control; observational study
dc.subject.meshHumans
dc.subject.meshDiabetes Mellitus
dc.subject.meshPrediabetic State
dc.subject.meshBlood Glucose
dc.subject.meshCholecystectomy
dc.subject.meshCross-Sectional Studies
dc.subject.meshAdult
dc.subject.meshGlycated Hemoglobin
dc.titleCholecystectomy is associated with dysglycaemia: cross-sectional and prospective analyses.
dc.typeJournal article
pubs.publication-statusPublished

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