Immune protection of hepatitis B vaccine among children living in Gondar, northwest Ethiopia
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Date
2019
Authors
Ayalew, G.
Assefa, A.
Amsalu, A.
Geta, M.
Mihret, A.
Aseffa, A.
Howe, R.
Abate, E.
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Ethiopian Medical Journal, 2019; 57(2):137-144
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Abstract
Background: Hepatitis B virus infection is a worldwide health problem and highly endemic in developing countries including Ethiopia. Hepatitis B vaccine is included in the routine Expanded Program on Immunization since 2007 in Ethiopia.
Objective: The aim of this study was to assess the sero-protection level of hepatitis B vaccination among children who have received the vaccine.
Methods: A cross-sectional study was conducted among children attending Kindergarten and first cycle elementary school in Gondar town. A pre-tested structured questionnaire was used to collect the socio-demographic data. Blood sample was collected and serum separated for anti-HBs,anti-HBc and HBsAg. The data was analyzed using SPSS statistical software version 20. Binary logistic regression analysis was done. P-value less than 0.05 was considered as statistically significant.
Result:Out of 431 children screened, 27 were excluded from analysis because they were positive for anti-HBc(27/431, 6.3%) and/or for HBsAg (18/431 or 4.2%). Out of 404 children, 130 (32.2%) had anti-HBs titers >10 mIU/ml (seroprotected) while 274 (68.8%) had anti-HBs titers <10 mIU/ml (non-protected).
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Copyright 2019 The author(s).