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A low-intensity nutrition intervention targeting triglycerides in gestational diabetes: a feasibility RCT

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dc.contributor.authorLiu, K.
dc.contributor.authorClarke, G.S.
dc.contributor.authorGrieger, J.A.
dc.date.issued2026
dc.descriptionAdvance access publication 16 May 2025
dc.description.abstractContext The conventional approach to diet therapy for gestational diabetes mellitus (GDM) is carbohydrate modification to mitigate glucose-mediated fetal macrosomia. Maternal triglyceride concentrations more strongly relate to infant adiposity than maternal glucose. Objective This work aimed to assess the feasibility of a low-intensity dietary intervention designed to attenuate the rise in triglycerides compared to standard GDM management. Methods Women with GDM were randomly assigned at approximately 30 weeks’ gestation to a standard care group (ie, usual GDM management) or to an intervention group, at an allocation ratio of 1:1. The intervention group received standard care plus individual counseling on reducing intake of ultraprocessed foods, increasing fruits, vegetables, fish and nuts, and changes to healthier fats. The primary outcome is study feasibility; secondary and exploratory outcomes include maternal dietary intakes, plasma triglyceride and glucose levels, and birth weight. Results Over 10 months of active recruitment, 444 women were invited to participate. Of these, 59 were eligible (13.2%), 38 (8.6%) consented and were randomly assigned (n = 19 intervention, n = 19 standard care), and 34 women completed the study. The recruitment rate was 1 per week, the retention rate was 89.5%, and the feasibility of eligibility criteria was 70.4%. Nearly all women in the intervention group who responded to the questionnaire (n = 15/16) reduced their ultraprocessed food intake, and 11 women increased their intake of nuts. There was no end of study differences in nonfasting plasma triglycerides (mean [95% CI] in intervention, 2.84 [2.22-3.46] mmol/L vs standard care, 3.40 [2.78-4.02] mmol/L). Mean birthweight was higher in the standard care group vs intervention group (mean difference [95% CI], 479.5 [110.7-848.3] g). Conclusion There was a modest recruitment rate and a high retention rate, indicating a diet aimed at attenuating triglycerides is feasible and highly acceptable in women with GDM. The positive improvements observed in maternal diet and desirable birth weight warrant further investigation in a larger, definitive, randomized controlled trial.
dc.description.statementofresponsibilityKai Liu, Georgia S. Clarke, Jessica A. Grieger
dc.identifier.citationJournal of Clinical Endocrinology and Metabolism (JCEM), 2026; 111(1):218-228
dc.identifier.doi10.1210/clinem/dgaf291
dc.identifier.issn0021-972X
dc.identifier.issn1945-7197
dc.identifier.orcidLiu, K. [0000-0003-3633-1226]
dc.identifier.orcidClarke, G.S. [0000-0003-3303-6512]
dc.identifier.orcidGrieger, J.A. [0000-0003-1515-948X]
dc.identifier.urihttps://hdl.handle.net/2440/147458
dc.language.isoen
dc.publisherOxford University Press
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/2000905
dc.rights© The Author(s) 2025. Published by Oxford University Press on behalf of the Endocrine Society. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. See the journal About page for additional terms.
dc.source.urihttps://doi.org/10.1210/clinem/dgaf291
dc.subjectDietary Intervention
dc.subjectFeasibility Studies
dc.subjectGestational Diabetes
dc.subjectPregnancy
dc.subjectPrenatal Care
dc.titleA low-intensity nutrition intervention targeting triglycerides in gestational diabetes: a feasibility RCT
dc.typeJournal article
pubs.publication-statusPublished

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