Secretor status is a modifier of vaginal microbiota-associated preterm birth risk.

Simple item page
dc.contributor.authorKundu, S.
dc.contributor.authorDos Santos Correia, G.
dc.contributor.authorLee, Y.S.
dc.contributor.authorNg, S.
dc.contributor.authorSykes, L.
dc.contributor.authorChan, D.
dc.contributor.authorLewis, H.
dc.contributor.authorBrown, R.G.
dc.contributor.authorKindinger, L.
dc.contributor.authorDell, A.
dc.contributor.authorFeizi, T.
dc.contributor.authorHaslam, S.M.
dc.contributor.authorLiu, Y.
dc.contributor.authorMarchesi, J.R.
dc.contributor.authorMacIntyre, D.A.
dc.contributor.authorBennett, P.R.
dc.date.issued2024
dc.description.abstractMutations in the FUT2 gene that result in a lack of expression of histo-blood group antigens on secreted glycoproteins may shape the vaginal microbiota with consequences for birth outcome. To test this, we analysed the relationship between secretor status, vaginal microbiota and gestational length in an ethnically diverse cohort of 302 pregnant women, including 82 who delivered preterm. Lactobacillus gasseri and L. jensenii were found to have distinct co-occurrence patterns with other microbial taxa in non-secretors. Moreover, non-secretors with Lactobacillus spp. depleted high diversity vaginal microbiota in early pregnancy had significantly shorter gestational length than Lactobacillus spp. dominated non-secretors (mean of 241.54 days (sd=47.14) versus 266.21 (23.61); P-value= 0.0251). Similar gestational length differences were observed between non-secretors with high vaginal diversity and secretors with Lactobacillus spp. dominance (mean of 262.52 days (SD=27.73); p-value= 0.0439) or depletion (mean of 266.05 days (SD=20.81); p-value= 0.0312). Our data highlight secretor status and blood-group antigen expression as being important mediators of vaginal microbiota–host interactions in the context of preterm birth risk.
dc.description.statementofresponsibilitySamit Kundu, Gonçalo dos Santos Correia, Yun S. Lee, Sherrianne Ng, Lynne Sykes, Denise Chan, Holly Lewis, Richard G. Brown, Lindsay Kindinger, Anne Dell, Ten Feizi, Stuart M. Haslam, Yan Liu, Julian R. Marchesi, David A. MacIntyre, and Phillip R. Bennett
dc.identifier.citationMicrobial Genomics, 2024; 10(12):001323-1-001323-11
dc.identifier.doi10.1099/mgen.0.001323
dc.identifier.issn2057-5858
dc.identifier.issn2057-5858
dc.identifier.orcidMacIntyre, D.A. [0000-0002-4186-5567]
dc.identifier.urihttps://hdl.handle.net/2440/146601
dc.language.isoen
dc.publisherMicrobiology Society
dc.rights© 2024 The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution
dc.source.urihttps://doi.org/10.1099/mgen.0.001323
dc.subjectblood-type antigens; Lactobacillus; preterm birth; secretor status and vaginal microbiome
dc.subject.meshVagina
dc.subject.meshHumans
dc.subject.meshLactobacillus
dc.subject.meshPremature Birth
dc.subject.meshFucosyltransferases
dc.subject.meshPregnancy
dc.subject.meshAdult
dc.subject.meshInfant, Newborn
dc.subject.meshFemale
dc.subject.meshMicrobiota
dc.subject.meshLactobacillus gasseri
dc.subject.meshGalactoside 2-alpha-L-fucosyltransferase
dc.titleSecretor status is a modifier of vaginal microbiota-associated preterm birth risk.
dc.typeJournal article
pubs.publication-statusPublished

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
hdl_146601.pdf
Size:
2.94 MB
Format:
Adobe Portable Document Format
Description:
Published version
Download

Collections

Research Outputs