Acute effects of whey protein, alone and mixed with other macronutrients, on blood pressure and heart rate in older men.

Simple item page
dc.contributor.authorOberoi, A.
dc.contributor.authorGiezenaar, C.
dc.contributor.authorLange, K.
dc.contributor.authorJones, K.L.
dc.contributor.authorHorowitz, M.
dc.contributor.authorChapman, I.
dc.contributor.authorSoenen, S.
dc.date.issued2022
dc.description.abstractBackground: Caloric supplements are increasingly used by older people, aiming to increase their daily protein intake. These high caloric drinks, rich in glucose and whey-protein in particular, may result in potential harmful decreases in blood pressure (BP). The effect of ingesting whey-protein with glucose and fat on BP is unknown. It has also been assumed that the maximum fall in systolic blood pressure occurs within 2 h of a meal. Methods: This study aimed to determine in older men, the effects of whey-protein, alone and mixed with other macronutrients, on systolic (SBP) and diastolic (DBP) blood pressure and heart rate (HR) in older men for 3 h. Thirteen older men (age 75 ± 2yrs; body mass index (BMI) 25.6 ± 0.6 kg/m²) ingested a drink on separate study days: (i) 70 g whey-protein ( P₂₈₀); (ii) 14 g whey-protein, 28 g carbohydrate, 12.4 g fat ( M₂₈₀); (iii) 70 g whey-protein, 28 g carbohydrate, 12.4 g fat ( M₅₀₄); or (iv) a non-caloric control drink (C). Results: SBP decreased after all three nutrient drinks compared to the C, with the greatest reduction after the M504 drink (P = 0.008). Maximal decreases in SBP (C: -14 ± 2 mmHg, P₂₈₀: -22 ± 2 mmHg, M₂₈₀: -22 ± 4 mmHg, M₅₀₄: -24 ± 3 mmHg) occurred about 2 h after drink ingestion and this fall was sustained thereafter (120-180 min: P₂₈₀ and M₅₀₄ vs. C P < 0.05). Maximum DBP decreases and HR increases occurred after M₅₀₄, with no differences between the effects of the P₂₈₀ and M₂₈₀ drinks. Conclusions: The effects of whey-protein containing drinks to lower BP and increase HR appear to be primarily dependent on their energy content rather than macronutrient composition and may persist for at least 3 h after ingestion,. Pure whey-protein drinks may represent the best approach to maximize protein intake without increasing the potential for deleterious BP falls in older people. Trial registration: ACTRN 12614 00084 6628, 14/03/2019.
dc.description.statementofresponsibilityAvneet Oberoi, Caroline Giezenaar, Kylie Lange, Karen L. Jones, Michael Horowitz, Ian Chapman, and Stijn Soenen
dc.identifier.citationBMC Geriatrics, 2022; 22(1):535-1-535-6
dc.identifier.doi10.1186/s12877-022-03213-1
dc.identifier.issn1471-2318
dc.identifier.issn1471-2318
dc.identifier.orcidOberoi, A. [0000-0003-0517-8257]
dc.identifier.orcidLange, K. [0000-0003-3814-8513]
dc.identifier.orcidJones, K.L. [0000-0002-1155-5816]
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]
dc.identifier.orcidSoenen, S. [0000-0002-0196-128X]
dc.identifier.urihttps://hdl.handle.net/2440/146150
dc.language.isoen
dc.publisherBMC
dc.rights© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
dc.source.urihttps://doi.org/10.1186/s12877-022-03213-1
dc.subjectAging; Diet; Whey protein; Blood pressure; Heart rate
dc.subject.meshHumans
dc.subject.meshGlucose
dc.subject.meshBlood Pressure
dc.subject.meshHeart Rate
dc.subject.meshAged
dc.subject.meshMale
dc.subject.meshWhey Proteins
dc.subject.meshNutrients
dc.titleAcute effects of whey protein, alone and mixed with other macronutrients, on blood pressure and heart rate in older men.
dc.typeJournal article
pubs.publication-statusPublished

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
hdl_146150.pdf
Size:
923.9 KB
Format:
Adobe Portable Document Format
Description:
Published version
Download

Collections

Research Outputs