Energy-dense vs routine enteral nutrition in New Zealand Europeans, Māori, and Pacific Peoples who are critically ill.

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dc.contributor.authorReid, A.L.
dc.contributor.authorChapman, M.J.
dc.contributor.authorPeake, S.L.
dc.contributor.authorBellomo, R.
dc.contributor.authorDavies, A.
dc.contributor.authorDeane, A.M.
dc.contributor.authorHorowitz, M.
dc.contributor.authorHurford, S.
dc.contributor.authorLange, K.
dc.contributor.authorLittle, L.
dc.contributor.authorMackle, D.
dc.contributor.authorO'Connor, S.N.
dc.contributor.authorRidley, E.J.
dc.contributor.authorWilliams, P.J.
dc.contributor.authorYoung, P.J.
dc.date.issued2020
dc.description.abstractAims: To evaluate the effect of energy-dense vs routine enteral nutrition on day-90 mortality by ethnic group in critically ill adults. Methods: Pre-planned subgroup analysis of the 1,257 New Zealanders in a 4,000-participant randomised trial comparing energy-dense enteral nutrition (1.5kcal/mL) with routine enteral nutrition (1kcal/mL) in mechanically ventilated intensive care unit (ICU) patients. The primary purpose of this analysis was to evaluate responses to study treatment by ethnic group (European, Maori, and Pacific Peoples) using ethnicity data recorded in the clinical records. The secondary purpose was to compare the characteristics and outcomes of patients by ethnic group. The primary outcome was day-90 mortality. Results: Among 1,138 patients included in the primary outcome analysis, 165 of 569 (29.0%) assigned to energy-dense nutrition and 156 of 569 patients (27.4%) assigned to routine nutrition died by day 90 (odds ratio; 1.06; 95% CI, 0.92–1.22). There was no statistically significant interaction between treatment allocation and ethnicity with respect to day-90 mortality. Day-90 mortality rates did not vary statistically significantly by ethnic group. Conclusions: Among mechanically ventilated adults in New Zealand ICUs, the effect on day-90 mortality of energy-dense vs routine enteral nutrition did not vary by ethnicity.
dc.description.statementofresponsibilityAlice L. Reid, Marianne J. Chapman, Sandra L. Peake, Rinaldo Bellomo, Andrew R. Davies, Adam M. Deane, Michael Horowitz, Sally Hurford, Kylie Lange, Lorraine Little, Diane M. Mackle, Stephanie N. O'Connor, Jeffrey J. Presneill, Emma J. Ridley, Patricia J. Williams, Paul J. Young, on behalf of the TARGET Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group
dc.identifier.citationNew Zealand Medical Journal, 2020; 133(1516):72-82
dc.identifier.issn1175-8716
dc.identifier.issn1175-8716
dc.identifier.orcidChapman, M.J. [0000-0003-0710-3283]
dc.identifier.orcidPeake, S.L. [0000-0001-6682-7973]
dc.identifier.orcidDeane, A.M. [0000-0002-7620-5577]
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]
dc.identifier.orcidLange, K. [0000-0003-3814-8513]
dc.identifier.orcidO'Connor, S.N. [0000-0002-4177-4059]
dc.identifier.orcidWilliams, P.J. [0000-0002-3948-5573]
dc.identifier.urihttps://hdl.handle.net/2440/145882
dc.language.isoen
dc.publisherNew Zealand Medical Association
dc.rights© NZMA
dc.source.urihttps://nzmj.org.nz/
dc.subjectenergy-dense vs routine enteral nutrition; mortality; Illness; Ethical groups; study; Eurpean; Maori; Pacific Peoples; Comparison study; Adult; New Zealand; Australia
dc.subject.meshHumans
dc.subject.meshCritical Illness
dc.subject.meshEnteral Nutrition
dc.subject.meshMortality
dc.subject.meshSurvival Analysis
dc.subject.meshEnergy Intake
dc.subject.meshAdult
dc.subject.meshMiddle Aged
dc.subject.meshNew Zealand
dc.subject.meshFemale
dc.subject.meshMale
dc.subject.meshIntention to Treat Analysis
dc.subject.meshNative Hawaiian or Other Pacific Islander
dc.subject.meshWhite People
dc.titleEnergy-dense vs routine enteral nutrition in New Zealand Europeans, Māori, and Pacific Peoples who are critically ill.
dc.typeJournal article
pubs.publication-statusPublished

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