Identification of placental androgen receptor isoforms in a sheep model of maternal allergic asthma

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dc.contributor.authorMeakin, A.S.
dc.contributor.authorMorrison, J.L.
dc.contributor.authorBradshaw, E.L.
dc.contributor.authorHolman, S.L.
dc.contributor.authorSaif, Z.
dc.contributor.authorGatford, K.L.
dc.contributor.authorWallace, M.J.
dc.contributor.authorBischof, R.J.
dc.contributor.authorMoss, T.J.M.
dc.contributor.authorClifton, V.L.
dc.date.issued2021
dc.description.abstractMaternal asthma is known to impact intrauterine growth outcomes, which may be mediated, in part, by altered androgen signalling. Our aim was to explore whether the sheep placenta expresses androgen receptor (AR) isoforms and determine if the differential expression of AR protein isoforms is altered by maternal asthma. Four known AR isoforms were detected (AR-FL, AR-v1, AR-v7, and AR-45), and their expression and subcellular distribution was altered in the presence of maternal allergic asthma. These findings underscore the importance for in vivo models of maternal asthma to delineate molecular patterns that may contribute to feto-placental growth and development.
dc.description.statementofresponsibilityAshley S. Meakin, Janna L. Morrison, Emma L. Bradshaw, Stacey L. Holman, Zarqa Saif, Kathryn L. Gatford, Megan J. Wallace, Robert J. Bischof, Timothy J.M. Moss, Vicki L. Clifton
dc.identifier.citationPlacenta, 2021; 104:232-235
dc.identifier.doi10.1016/j.placenta.2021.01.003
dc.identifier.issn0143-4004
dc.identifier.issn1532-3102
dc.identifier.orcidGatford, K.L. [0000-0002-2823-3004]
dc.identifier.orcidClifton, V.L. [0000-0002-4892-6748]
dc.identifier.urihttp://hdl.handle.net/2440/130821
dc.language.isoen
dc.publisherElsevier BV
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1043294
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1041918
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1136100
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1066916
dc.relation.granthttp://purl.org/au-research/grants/arc/FT170100431
dc.rightsCrown Copyright © 2021 Published by Elsevier Ltd. All rights reserved.
dc.source.urihttps://doi.org/10.1016/j.placenta.2021.01.003
dc.subjectAndrogen; androgen receptor; sheep; asthma
dc.titleIdentification of placental androgen receptor isoforms in a sheep model of maternal allergic asthma
dc.typeJournal article
pubs.publication-statusPublished

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