LDL receptor regulation in human liver cells by dietary fatty acids and antioxidants / Sebely Pal.
Date
1996
Authors
Pal, Sebely
Editors
Advisors
Journal Title
Journal ISSN
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Type:
Thesis
Citation
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Abstract
Demonstrates that fatty acids and antioxidants can regulate the low density lipoprotein (LDL) receptor at the level of gene transcription in cultured liver cells. EPA and linoleic acid (PUFAs) are specifically shown to downregulate the LDL receptor compared to saturated and monosaturated fatty acids in the presence or absence of cholesterol. The experiments lead to the discovery that antioxidants can upregulate the LDL receptor in the human HepG2 cells.
School/Discipline
Dept. of Animal Sciences
Dissertation Note
Thesis (Ph.D.)--University of Adelaide, Dept. of Animal Science, 1996
Provenance
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Description
Erratum final three leaves of thesis.
Includes bibliographical references (leaves 266-288).
xvi, 288, [3] leaves : ill. ; 30 cm.
Includes bibliographical references (leaves 266-288).
xvi, 288, [3] leaves : ill. ; 30 cm.