TRPV1 channels and gastric vagal afferent signalling in lean and high fat diet induced obese mice
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(Published version)
Date
2015
Authors
Kentish, S.
Frisby, C.
Kritas, S.
Li, H.
Hatzinikolas, G.
O'Donnell, T.
Wittert, G.
Page, A.
Editors
Cota, D.
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Journal article
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PLoS ONE, 2015; 10(8):e0135892-1-e0135892-15
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Stephen J. Kentish, Claudine L. Frisby, Stamatiki Kritas, Hui Li, George Hatzinikolas, Tracey A. O, Donnell, Gary A. Wittert, Amanda J. Page
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Abstract
Within the gastrointestinal tract vagal afferents play a role in control of food intake and satiety signalling. Activation of mechanosensitive gastric vagal afferents induces satiety. However, gastric vagal afferent responses to mechanical stretch are reduced in high fat diet mice. Transient receptor potential vanilloid 1 channels (TRPV1) are expressed in vagal afferents and knockout of TRPV1 reduces gastro-oesophageal vagal afferent responses to stretch. We aimed to determine the role of TRPV1 on gastric vagal afferent mechanosensitivity and food intake in lean and HFD-induced obese mice.
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© 2015 Kentish et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.