TRPV1 channels and gastric vagal afferent signalling in lean and high fat diet induced obese mice

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dc.contributor.authorKentish, S.
dc.contributor.authorFrisby, C.
dc.contributor.authorKritas, S.
dc.contributor.authorLi, H.
dc.contributor.authorHatzinikolas, G.
dc.contributor.authorO'Donnell, T.
dc.contributor.authorWittert, G.
dc.contributor.authorPage, A.
dc.contributor.editorCota, D.
dc.date.issued2015
dc.description.abstractWithin the gastrointestinal tract vagal afferents play a role in control of food intake and satiety signalling. Activation of mechanosensitive gastric vagal afferents induces satiety. However, gastric vagal afferent responses to mechanical stretch are reduced in high fat diet mice. Transient receptor potential vanilloid 1 channels (TRPV1) are expressed in vagal afferents and knockout of TRPV1 reduces gastro-oesophageal vagal afferent responses to stretch. We aimed to determine the role of TRPV1 on gastric vagal afferent mechanosensitivity and food intake in lean and HFD-induced obese mice.
dc.description.statementofresponsibilityStephen J. Kentish, Claudine L. Frisby, Stamatiki Kritas, Hui Li, George Hatzinikolas, Tracey A. O, Donnell, Gary A. Wittert, Amanda J. Page
dc.identifier.citationPLoS ONE, 2015; 10(8):e0135892-1-e0135892-15
dc.identifier.doi10.1371/journal.pone.0135892
dc.identifier.issn1932-6203
dc.identifier.issn1932-6203
dc.identifier.orcidKentish, S. [0000-0002-5479-2643]
dc.identifier.orcidLi, H. [0000-0002-1010-516X]
dc.identifier.orcidHatzinikolas, G. [0000-0001-5430-6396]
dc.identifier.orcidWittert, G. [0000-0001-6818-6065]
dc.identifier.orcidPage, A. [0000-0002-7086-5865]
dc.identifier.urihttp://hdl.handle.net/2440/94719
dc.language.isoen
dc.publisherPublic Library of Science
dc.rights© 2015 Kentish et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.source.urihttps://doi.org/10.1371/journal.pone.0135892
dc.subjectEsophagus
dc.subjectStomach
dc.subjectVagus Nerve
dc.subjectAdipose Tissue
dc.subjectAnimals
dc.subjectMice, Inbred C57BL
dc.subjectMice
dc.subjectMice, Obese
dc.subjectObesity
dc.subjectBody Weight
dc.subjectSignal Transduction
dc.subjectMechanotransduction, Cellular
dc.subjectEating
dc.subjectMale
dc.subjectTRPV Cation Channels
dc.subjectGene Knockout Techniques
dc.subjectDiet, High-Fat
dc.titleTRPV1 channels and gastric vagal afferent signalling in lean and high fat diet induced obese mice
dc.typeJournal article
pubs.publication-statusPublished

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