Relationship between cerebral aneurysms and variations in cerebral basal arterial network: a morphometric cross-sectional study in Computed Tomography Angiograms from a neurointerventional unit

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dc.contributor.authorBurlakoti, A.
dc.contributor.authorKumaratilake, J.
dc.contributor.authorTaylor, J.
dc.contributor.authorHenneberg, M.
dc.date.issued2021
dc.description.abstractObjective: Segments of cerebral basal arterial network (CBAN) dampen the peak pressure in blood flowing through these arteries, thus minimising the chances of development of cerebral aneurysms. The objective of this research was to find the relationship of occurrence of intracranial aneurysms to variations of the components of the CBAN. Design and setting: This is an observational, quantitative and retrospective research, which used cerebral CT angiography (CCTA) images. Participants: Cerebral CTA of 145 adult patients of both sexes were studied. Main outcome measures: Diameters of segments of CBAN were measured in CCTA images and the relative size of each vessel was calculated to standardise for differences in overall arterial sizes among patients. Relationships among sizes of CBAN components were analysed. Presence of aneurysms in different parts of the CBAN was recorded. Results: Forty-six aneurysms in right internal carotid artery (ICA) and middle cerebral artery (MCA) and 32 aneurysms in left ICA and MCA segments were noted in 42 and 30 patients, respectively. Aneurysms in anterior communicating artery complex and vertebral-basilar arterial segments were seen in 27 and 8 patients, respectively, while they were not detected in parts of posterior cerebral artery (PCA). The significant (p<0.001) inverse relationships between sizes of posterior communicating artery and the first segment of PCA on both sides indicated that blood inputs to the second part of PCA were similar. Difference in means of the index of arterial size variation for people with aneurysms (mean 0.96, SD 0.23) and without aneurysms (mean 0.86, SD 0.22) was significant (p=0.015). Conclusion: Variation in segments of CBAN was quantified. The peak pressure dampening mechanism in such arterial segments reduces the chances of development of aneurysms.
dc.description.statementofresponsibilityArjun Burlakoti, Jaliya Kumaratilake, Jamie Taylor, Maciej Henneberg
dc.identifier.citationBMJ Open, 2021; 11(9):e051028-1-e051028-8
dc.identifier.doi10.1136/bmjopen-2021-051028
dc.identifier.issn2044-6055
dc.identifier.issn2044-6055
dc.identifier.orcidBurlakoti, A. [0000-0001-9317-6352]
dc.identifier.orcidKumaratilake, J. [0000-0001-5904-7629]
dc.identifier.orcidHenneberg, M. [0000-0003-1941-2286]
dc.identifier.urihttps://hdl.handle.net/2440/145802
dc.language.isoen
dc.publisherBMJ
dc.relation.grantARC
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/940286
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/971343
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/519211
dc.rights© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. Open access This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
dc.source.urihttps://doi.org/10.1136/bmjopen-2021-051028
dc.subjectcerebral basal arterial network (CBAN); blood flow; cerebral aneurysms; intracranial aneurysms
dc.subject.meshCarotid Artery, Internal
dc.subject.meshHumans
dc.subject.meshIntracranial Aneurysm
dc.subject.meshTomography, X-Ray Computed
dc.subject.meshCerebral Angiography
dc.subject.meshRetrospective Studies
dc.subject.meshCross-Sectional Studies
dc.subject.meshAdult
dc.subject.meshFemale
dc.subject.meshMale
dc.titleRelationship between cerebral aneurysms and variations in cerebral basal arterial network: a morphometric cross-sectional study in Computed Tomography Angiograms from a neurointerventional unit
dc.typeJournal article
pubs.publication-statusPublished

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