The Potential of alpha-Mangostin from Garcinia mangostana as an Effective Antimicrobial Agent-A Systematic Review and Meta-Analysis

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dc.contributor.authorSultan, O.S.
dc.contributor.authorKantilal, H.K.
dc.contributor.authorKhoo, S.P.
dc.contributor.authorDavamani, A.F.
dc.contributor.authorEusufzai, S.Z.
dc.contributor.authorRashid, F.
dc.contributor.authorBin Jamayet, N.
dc.contributor.authorSoh, J.A.
dc.contributor.authorTan, Y.Y.
dc.contributor.authorAlam, M.K.
dc.date.issued2022
dc.description.abstractThis systematic review aims to evaluate the antimicrobial activity of α-mangostin derived from Garcinia mangostana against different microbes. A literature search was performed using PubMed and Science Direct until March 2022. The research question was developed based on a PICO (Population, Intervention, Control and Outcomes) model. In this study, the population of interest was microbes, α-mangostin extracted from Garcinia mangostana was used as exposure while antibiotics were used as control, followed by the outcome which is determined by the antimicrobial activity of α-mangostin against studied microbes. Two reviewers independently performed the comprehensive literature search following the predetermined inclusion and exclusion criteria. A methodological quality assessment was carried out using a scoring protocol and the risk of bias in the studies was analyzed. Reward screening was performed among the selected articles to perform a meta-analysis based on the pre-determined criteria. Case groups where α-mangostin extracted from Garcinia mangostana was incorporated were compared to groups using different antibiotics or antiseptic agents (control) to evaluate their effectiveness. A total of 30 studies were included; they were heterogeneous in their study design and the risk of bias was moderate. The results showed a reduction in microbial counts after the incorporation of α-mangostin, which resulted in better disinfection and effectiveness against multiple microbes. Additionally, the meta-analysis result revealed no significant difference (p > 0.05) in their effectiveness when α-mangostin was compared to commercially available antibiotics. α-mangostin worked effectively against the tested microbes and was shown to have inhibitory effects on microbes with antibiotic resistance.
dc.description.statementofresponsibilityOmer Sheriff Sultan, Haresh Kumar Kantilal, Suan Phaik Khoo, Amalraj Fabian Davamani, Sumaiya Zabin Eusufzai, Farah Rashid, Nafij Bin Jamayet, Jue Ann Soh, Yen Yee Tan, and Mohammad Khursheed Alam
dc.identifier.citationAntibiotics, 2022; 11(6):717-1-717-22
dc.identifier.doi10.3390/antibiotics11060717
dc.identifier.issn2079-6382
dc.identifier.issn2079-6382
dc.identifier.orcidRashid, F. [0000-0002-2017-2454]
dc.identifier.urihttps://hdl.handle.net/2440/145948
dc.language.isoen
dc.publisherMDPI AG
dc.rights© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
dc.source.urihttps://doi.org/10.3390/antibiotics11060717
dc.subjectantimicrobial
dc.subjectGarcinia mangostana
dc.subjectα-mangostin
dc.titleThe Potential of alpha-Mangostin from Garcinia mangostana as an Effective Antimicrobial Agent-A Systematic Review and Meta-Analysis
dc.typeJournal article
pubs.publication-statusPublished

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