Measuring and Modelling the Epithelial- Mesenchymal Hybrid State in Cancer: Clinical Implications
Date
2022
Authors
Jolly, M.K.
Murphy, R.J.
Bhatia, S.
Whitfield, H.J.
Redfern, A.
Davis, M.J.
Thompson, E.W.
Editors
Advisors
Journal Title
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Volume Title
Type:
Journal article
Citation
Cells, Tissues, Organs: in vivo, in vitro, 2022; 211(2):110-133
Statement of Responsibility
Mohit Kumar Jolly, Ryan J. Murphy, Sugandha Bhatia, Holly J. Whitfield, Andrew Redfern, Melissa J. Davis, Erik W. Thompson
Conference Name
Abstract
The epithelial-mesenchymal (E/M) hybrid state has emerged as an important mediator of elements of cancer progression, facilitated by epithelial mesenchymal plasticity (EMP). We review here evidence for the presence, prognostic significance, and therapeutic potential of the E/M hybrid state in carcinoma. We further assess modelling predictions and validation studies to demonstrate stabilised E/M hybrid states along the spectrum of EMP, as well as computational approaches for characterising and quantifying EMP phenotypes, with particular attention to the emerging realm of single-cell approaches through RNA sequencing and protein-based techniques.
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Dissertation Note
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© 2021 S. Karger AG, Basel