Measuring and Modelling the Epithelial- Mesenchymal Hybrid State in Cancer: Clinical Implications

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dc.contributor.authorJolly, M.K.
dc.contributor.authorMurphy, R.J.
dc.contributor.authorBhatia, S.
dc.contributor.authorWhitfield, H.J.
dc.contributor.authorRedfern, A.
dc.contributor.authorDavis, M.J.
dc.contributor.authorThompson, E.W.
dc.date.issued2022
dc.description.abstractThe epithelial-mesenchymal (E/M) hybrid state has emerged as an important mediator of elements of cancer progression, facilitated by epithelial mesenchymal plasticity (EMP). We review here evidence for the presence, prognostic significance, and therapeutic potential of the E/M hybrid state in carcinoma. We further assess modelling predictions and validation studies to demonstrate stabilised E/M hybrid states along the spectrum of EMP, as well as computational approaches for characterising and quantifying EMP phenotypes, with particular attention to the emerging realm of single-cell approaches through RNA sequencing and protein-based techniques.
dc.description.statementofresponsibilityMohit Kumar Jolly, Ryan J. Murphy, Sugandha Bhatia, Holly J. Whitfield, Andrew Redfern, Melissa J. Davis, Erik W. Thompson
dc.identifier.citationCells Tissues Organs, 2022; 211(2):110-133
dc.identifier.doi10.1159/000515289
dc.identifier.issn1422-6405
dc.identifier.issn1422-6421
dc.identifier.orcidDavis, M.J. [0000-0003-4864-7033]
dc.identifier.urihttps://hdl.handle.net/2440/137192
dc.language.isoen
dc.publisherS. Karger AG
dc.rights© 2021 S. Karger AG, Basel
dc.source.urihttps://doi.org/10.1159/000515289
dc.subjectEpithelial-mesenchymal plasticity
dc.subjectEpithelial-mesenchymal transition; Mesenchymal- epithelial transition; E/M hybrid
dc.subjectPartial epithelial- mesenchymal plasticity
dc.subjectComputational biology
dc.subjectMolecular modelling
dc.subjectCancer
dc.subject.meshHumans
dc.subject.meshNeoplasms
dc.subject.meshEpithelial-Mesenchymal Transition
dc.titleMeasuring and Modelling the Epithelial- Mesenchymal Hybrid State in Cancer: Clinical Implications
dc.typeJournal article
pubs.publication-statusPublished

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