The role of microglia in neuropsychiatric disorders and suicide

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dc.contributor.authorBrisch, R.
dc.contributor.authorWojtylak, S.
dc.contributor.authorSaniotis, A.
dc.contributor.authorSteiner, J.
dc.contributor.authorGos, T.
dc.contributor.authorKumaratilake, J.
dc.contributor.authorHenneberg, M.
dc.contributor.authorWolf, R.
dc.date.issued2022
dc.description.abstractThis narrative review examines the possible role of microglial cells, first, in neuroinflammation and, second, in schizophrenia, depression, and suicide. Recent research on the interactions between microglia, astrocytes and neurons and their involvement in pathophysiological processes of neuropsychiatric disorders is presented. This review focuses on results from postmortem, positron emission tomography (PET) imaging studies, and animal models of schizophrenia and depression. Third, the effects of antipsychotic and antidepressant drug therapy, and of electroconvulsive therapy on microglial cells are explored and the upcoming development of therapeutic drugs targeting microglia is described. Finally, there is a discussion on the role of microglia in the evolutionary progression of human lineage. This view may contribute to a new understanding of neuropsychiatric disorders.
dc.description.statementofresponsibilityRalf Brisch, Szymon Wojtylak, Arthur Saniotis, Johann Steiner, Tomasz Gos, Jaliya Kumaratilake, Maciej Henneberg, Rainer Wolf
dc.identifier.citationEuropean Archives of Psychiatry and Clinical Neuroscience, 2022; 272(6):929-945
dc.identifier.doi10.1007/s00406-021-01334-z
dc.identifier.issn0940-1334
dc.identifier.issn1433-8491
dc.identifier.orcidSaniotis, A. [0000-0002-9708-6220]
dc.identifier.orcidKumaratilake, J. [0000-0001-5904-7629]
dc.identifier.orcidHenneberg, M. [0000-0003-1941-2286]
dc.identifier.urihttps://hdl.handle.net/2440/145801
dc.language.isoen
dc.publisherSpringer (part of Springer Nature)
dc.rights© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
dc.source.urihttps://doi.org/10.1007/s00406-021-01334-z
dc.subjectMicroglia; Schizophrenia; Major depressive disorder; Bipolar disorder; Affective disorders; Suicide; Dorsal raphe nucleus; Serotonin; Evolution of human lineage
dc.subject.meshMicroglia
dc.subject.meshAnimals
dc.subject.meshHumans
dc.subject.meshPositron-Emission Tomography
dc.subject.meshSuicide
dc.subject.meshDepressive Disorder, Major
dc.subject.meshSchizophrenia
dc.titleThe role of microglia in neuropsychiatric disorders and suicide
dc.typeJournal article
pubs.publication-statusPublished online

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